Division of Gastroenterology, Aga Khan university, Karachi, Pakistan.
J Clin Gastroenterol. 2011 Mar;45(3):286-92. doi: 10.1097/MCG.0b013e3181f656fb.
Seizures are reported as an uncommon side effect of interferon therapy.
To determine the frequency and presentation of seizures occurring during pegylated interferon-α (PEG-IFNα) and ribavirin therapy for chronic hepatitis C.
Patients were identified using data from the WIN-R trial database, a US multicenter study comparing fixed (800 mg) versus weight-based (800 to 1400 mg) daily dosing of ribavirin in combination with PEG-IFNα-2b (1.5 μg/kg/wk).
Of the 4913 enrolled patients, 8 (0.16%) had a seizure. Three patients had a grand mal seizure and the seizure type was unknown in 5 patients. At the time of seizure, 6 patients were taking antidepressants (including 3 on bupropion), 1 was hyponatremic, and 1 had consumed a significant amount of alcohol. One patient had a history of seizures. Neuroimaging and electroencephalographic studies were negative. Antiepileptic medications were continued in the patient with a history of seizures and initiated in 1 patient. PEG-IFNα-2b plus ribavirin therapy was continued in 2 patients following seizure and neither experienced a recurrent seizure.
Seizures occur infrequently in patients receiving PEG-IFNα-2b plus ribavirin, and appear to be associated with other risk factors including antidepressant use.
癫痫发作是干扰素治疗的一种罕见副作用。
确定聚乙二醇干扰素-α（PEG-IFNα）和利巴韦林治疗慢性丙型肝炎期间发生癫痫的频率和表现。
使用来自 WIN-R 试验数据库的数据识别患者，这是一项美国多中心研究，比较了 PEG-IFNα-2b（1.5 μg/kg/周）联合利巴韦林固定剂量（800mg）与体重剂量（800-1400mg）每日给药的疗效。
在 4913 名入组患者中，有 8 名（0.16%）发生了癫痫。3 名患者出现大发作，5 名患者的癫痫类型未知。在癫痫发作时，6 名患者正在服用抗抑郁药（包括 3 名服用安非他酮），1 名患者低钠血症，1 名患者大量饮酒。1 名患者有癫痫发作病史。神经影像学和脑电图研究均为阴性。在有癫痫发作病史的患者中继续使用抗癫痫药物，在 1 名患者中开始使用。在癫痫发作后，2 名患者继续接受 PEG-IFNα-2b 联合利巴韦林治疗，均未再次发生癫痫发作。
在接受 PEG-IFNα-2b 联合利巴韦林治疗的患者中，癫痫发作并不常见，似乎与其他危险因素有关，包括抗抑郁药的使用。
