Department of Psychiatry and Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
Division of Hepatogastroenterology, Department of Medicine, China Medical University Hospital, Taichung, Taiwan. ; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Psychiatry Investig. 2015 Jan;12(1):142-5. doi: 10.4306/pi.2015.12.1.142. Epub 2015 Jan 12.
Interferon (IFN)-α therapy for chronic hepatitis C virus (HCV) infection is frequently associated with major depressive episodes. Bupropion, a commonly used antidepressant agent, has recently found to have strong anti-inflammatory effects in animal models. Despite of the theoretical relevancy, the antidepressant effect of bupropion in IFN-alpha-induced depression has never been studied. Ten HCV patients with IFN-α-induced depression were recruited to receive 8-week bupropion treatment and were assessed every 2 weeks for depressive symptoms by the Hamilton rating scale for depression (HAMD) and somatic symptoms by the Neurotoxicity Rating Scale (NRS). Four of the 10 patients met the criteria for remission (total HAMD scores≤7), and 5 patients met the criteria for response (at least 50% reduction in total HAMD scores). In addition, 5 patients had 50% decreases in NRS for neuropsychiatric symptoms. This preliminary open-label study suggests that bupropion is effective in treating IFN-alpha-induced depressive and somatic symptoms.
干扰素(IFN)-α 治疗慢性丙型肝炎病毒(HCV)感染常伴有重度抑郁发作。安非他酮是一种常用的抗抑郁药,最近在动物模型中发现具有很强的抗炎作用。尽管理论上相关,但安非他酮在 IFN-α 诱导的抑郁中的抗抑郁作用从未被研究过。10 名因 IFN-α 诱导的抑郁的 HCV 患者被招募接受 8 周的安非他酮治疗,并每 2 周通过汉密尔顿抑郁量表(HAMD)评估抑郁症状和神经毒性评定量表(NRS)评估躯体症状。4 名患者符合缓解标准(HAMD 总分≤7),5 名患者符合应答标准(HAMD 总分至少降低 50%)。此外,5 名患者的神经精神症状 NRS 降低了 50%。这项初步的开放标签研究表明,安非他酮治疗 IFN-α 诱导的抑郁和躯体症状有效。