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盐酸安非他酮治疗丙型肝炎病毒感染患者干扰素-α诱导的抑郁:一项开放标签研究。

Bupropion for interferon-alpha-induced depression in patients with hepatitis C viral infection: an open-label study.

机构信息

Department of Psychiatry and Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.

Division of Hepatogastroenterology, Department of Medicine, China Medical University Hospital, Taichung, Taiwan. ; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.

出版信息

Psychiatry Investig. 2015 Jan;12(1):142-5. doi: 10.4306/pi.2015.12.1.142. Epub 2015 Jan 12.

DOI:10.4306/pi.2015.12.1.142
PMID:25670957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4310912/
Abstract

Interferon (IFN)-α therapy for chronic hepatitis C virus (HCV) infection is frequently associated with major depressive episodes. Bupropion, a commonly used antidepressant agent, has recently found to have strong anti-inflammatory effects in animal models. Despite of the theoretical relevancy, the antidepressant effect of bupropion in IFN-alpha-induced depression has never been studied. Ten HCV patients with IFN-α-induced depression were recruited to receive 8-week bupropion treatment and were assessed every 2 weeks for depressive symptoms by the Hamilton rating scale for depression (HAMD) and somatic symptoms by the Neurotoxicity Rating Scale (NRS). Four of the 10 patients met the criteria for remission (total HAMD scores≤7), and 5 patients met the criteria for response (at least 50% reduction in total HAMD scores). In addition, 5 patients had 50% decreases in NRS for neuropsychiatric symptoms. This preliminary open-label study suggests that bupropion is effective in treating IFN-alpha-induced depressive and somatic symptoms.

摘要

干扰素(IFN)-α 治疗慢性丙型肝炎病毒(HCV)感染常伴有重度抑郁发作。安非他酮是一种常用的抗抑郁药,最近在动物模型中发现具有很强的抗炎作用。尽管理论上相关,但安非他酮在 IFN-α 诱导的抑郁中的抗抑郁作用从未被研究过。10 名因 IFN-α 诱导的抑郁的 HCV 患者被招募接受 8 周的安非他酮治疗,并每 2 周通过汉密尔顿抑郁量表(HAMD)评估抑郁症状和神经毒性评定量表(NRS)评估躯体症状。4 名患者符合缓解标准(HAMD 总分≤7),5 名患者符合应答标准(HAMD 总分至少降低 50%)。此外,5 名患者的神经精神症状 NRS 降低了 50%。这项初步的开放标签研究表明,安非他酮治疗 IFN-α 诱导的抑郁和躯体症状有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/222e/4310912/8d1d018dbe01/pi-12-142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/222e/4310912/8d1d018dbe01/pi-12-142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/222e/4310912/8d1d018dbe01/pi-12-142-g001.jpg

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本文引用的文献

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Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial.ω-3 脂肪酸预防干扰素-α诱导的抑郁:一项随机对照试验的结果。
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Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a 'mind-body interface'?ω-3脂肪酸抗抑郁作用的生物学机制:鱼油如何作为“身心界面”发挥作用?
Neurosignals. 2009;17(2):144-52. doi: 10.1159/000198167. Epub 2009 Feb 4.
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Therapy of interferon-induced depression in chronic hepatitis C with citalopram: a randomised, double-blind, placebo-controlled study.用西酞普兰治疗慢性丙型肝炎中干扰素诱导的抑郁症:一项随机、双盲、安慰剂对照研究。
Gut. 2008 Apr;57(4):531-6. doi: 10.1136/gut.2007.131607. Epub 2007 Dec 13.
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