Chin N X, Neu H C
Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
J Chemother. 1990 Dec;2(6):343-7. doi: 10.1080/1120009x.1990.11739040.
We evaluated the combination of ofloxacin with piperacillin, gentamicin, vancomycin, rifampin, clindamycin, and metronidazole by the checkerboard agar dilution method against 165 isolates which included Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Pseudomonas aeruginosa, Providencia stuartii, Acinetobacter, Staphylococcus aureus, Bacteroides fragilis, and Citrobacter perfringens. Synergy of piperacillin-ofloxacin was demonstrated for 50% and 40% respectively of E. cloacae and P. aeruginosa. Some ofloxacin and piperacillin-resistant isolates were susceptible with the combination. Ofloxacin-gentamicin was indifferent for aerobic gram-negative species. Ofloxacin and vancomycin or gentamicin was indifferent for S. aureus and E. faecalis, but rifampin-ofloxacin showed addition. Combination of ofloxacin and metronidazole or clindamycin or erythromycin was indifferent for aerobic and anaerobic species. Ofloxacin could be combined with piperacillin with benefit against P. aeruginosa, but combination with aminoglycosides is not of benefit.
我们采用棋盘琼脂稀释法，评估了氧氟沙星与哌拉西林、庆大霉素、万古霉素、利福平、克林霉素及甲硝唑联合应用对165株分离菌的抗菌活性，这些分离菌包括大肠杆菌、肺炎克雷伯菌、阴沟肠杆菌、粘质沙雷菌、铜绿假单胞菌、斯氏普罗威登斯菌、不动杆菌、金黄色葡萄球菌、脆弱拟杆菌及产气荚膜梭菌。哌拉西林-氧氟沙星联合用药对50%的阴沟肠杆菌及40%的铜绿假单胞菌显示协同作用。一些对氧氟沙星和哌拉西林耐药的菌株对联合用药敏感。氧氟沙星-庆大霉素对需氧革兰阴性菌无协同作用。氧氟沙星与万古霉素或庆大霉素对金黄色葡萄球菌和粪肠球菌无协同作用，但利福平-氧氟沙星显示相加作用。氧氟沙星与甲硝唑、克林霉素或红霉素联合应用对需氧菌和厌氧菌无协同作用。氧氟沙星与哌拉西林联合应用对铜绿假单胞菌有益，但与氨基糖苷类联合应用无益处。
