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采用时间杀菌法测定左氧氟沙星（L-氧氟沙星）与苯唑西林对耐喹诺酮金黄色葡萄球菌的协同作用。

Synergy of levofloxacin (L-ofloxacin) and oxacillin against quinolone-resistant Staphylococcus aureus, measured by the time-kill method.

作者信息

Patel J A, Pachucki C T, Lentino J R

机构信息

Medical Service, Edward Hines, Jr., Veterans Affairs Hospital, Hines, Illinois 60141.

出版信息

Antimicrob Agents Chemother. 1993 Feb;37(2):339-41. doi: 10.1128/AAC.37.2.339.

DOI:10.1128/AAC.37.2.339
PMID:8452367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187664/
Abstract

The synergistic activity of levofloxacin and oxacillin against levofloxacin-resistant isolates of methicillin-resistant Staphylococcus aureus was tested by the time-kill method. The combination of levofloxacin at 1/4 the MIC for the isolate plus oxacillin at 8 micrograms/ml (< 1/4 the MIC) was synergistic against seven of nine isolates at 8 h, although no significant synergy was demonstrated at 24 h. This combination may prove to be effective against multidrug-resistant methicillin-resistant S. aureus, and further studies are warranted.

摘要

采用时间杀菌法检测了左氧氟沙星和苯唑西林对耐左氧氟沙星的耐甲氧西林金黄色葡萄球菌分离株的协同活性。左氧氟沙星浓度为分离株最低抑菌浓度（MIC）的1/4加上8微克/毫升苯唑西林（< MIC的1/4）的联合用药，在8小时时对9株分离株中的7株具有协同作用，尽管在24小时时未显示出显著协同作用。这种联合用药可能对多重耐药的耐甲氧西林金黄色葡萄球菌有效，值得进一步研究。

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本文引用的文献

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Antibacterial activity of coumermycin alone and in combination with other antibiotics.香豆霉素单独及与其他抗生素联合使用时的抗菌活性。
Antimicrob Agents Chemother. 1984 Jun;25(6):687-9. doi: 10.1128/AAC.25.6.687.
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Antibiotic susceptibility testing by a standardized single disk method.采用标准化单纸片法进行抗生素敏感性试验。
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Bactericidal effect of ofloxacin alone and combined with fosfomycin or vancomycin against Staphylococcus aureus in vitro and in sera from volunteers.
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4
Synthesis and antibacterial activities of optically active ofloxacin.光学活性氧氟沙星的合成及抗菌活性
Antimicrob Agents Chemother. 1986 Jan;29(1):163-4. doi: 10.1128/AAC.29.1.163.
5
In vitro activity of DR-3355, an optically active ofloxacin.光学活性氧氟沙星DR-3355的体外活性
Antimicrob Agents Chemother. 1988 Sep;32(9):1336-40. doi: 10.1128/AAC.32.9.1336.
6
Antimicrobial resistance of Staphylococcus aureus: genetic basis.金黄色葡萄球菌的抗菌耐药性：遗传基础
Microbiol Rev. 1987 Mar;51(1):88-134. doi: 10.1128/mr.51.1.88-134.1987.
7
Widespread quinolone resistance among methicillin-resistant Staphylococcus aureus isolates in a general hospital.一家综合医院中耐甲氧西林金黄色葡萄球菌分离株对喹诺酮类药物的广泛耐药性
Antimicrob Agents Chemother. 1989 Apr;33(4):593-4. doi: 10.1128/AAC.33.4.593.
8
Synergistic effect of quinolones and oxacillin on methicillin-resistant Staphylococcus species.喹诺酮类药物与苯唑西林对耐甲氧西林葡萄球菌属的协同作用。
Antimicrob Agents Chemother. 1989 Dec;33(12):2037-41. doi: 10.1128/AAC.33.12.2037.
9
Combination of ofloxacin and other antimicrobial agents.氧氟沙星与其他抗菌剂的联合使用。 不过你提供的原文“Combination of ofloxacin and other antimicrobial agents.”中多了一个“of”，正确的应该是“Combination of ofloxacin and other antimicrobial agents” 。
J Chemother. 1990 Dec;2(6):343-7. doi: 10.1080/1120009x.1990.11739040.
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Rapid development of ciprofloxacin resistance in methicillin-susceptible and -resistant Staphylococcus aureus.甲氧西林敏感和耐药金黄色葡萄球菌中对环丙沙星耐药性的快速发展。
J Infect Dis. 1991 Jun;163(6):1279-85. doi: 10.1093/infdis/163.6.1279.