采用时间杀菌法测定左氧氟沙星（L-氧氟沙星）与苯唑西林对耐喹诺酮金黄色葡萄球菌的协同作用。
Synergy of levofloxacin (L-ofloxacin) and oxacillin against quinolone-resistant Staphylococcus aureus, measured by the time-kill method.
作者信息
Patel J A, Pachucki C T, Lentino J R
机构信息
Medical Service, Edward Hines, Jr., Veterans Affairs Hospital, Hines, Illinois 60141.
出版信息
Antimicrob Agents Chemother. 1993 Feb;37(2):339-41. doi: 10.1128/AAC.37.2.339.
Abstract
The synergistic activity of levofloxacin and oxacillin against levofloxacin-resistant isolates of methicillin-resistant Staphylococcus aureus was tested by the time-kill method. The combination of levofloxacin at 1/4 the MIC for the isolate plus oxacillin at 8 micrograms/ml (< 1/4 the MIC) was synergistic against seven of nine isolates at 8 h, although no significant synergy was demonstrated at 24 h. This combination may prove to be effective against multidrug-resistant methicillin-resistant S. aureus, and further studies are warranted.
摘要
采用时间杀菌法检测了左氧氟沙星和苯唑西林对耐左氧氟沙星的耐甲氧西林金黄色葡萄球菌分离株的协同活性。左氧氟沙星浓度为分离株最低抑菌浓度（MIC）的1/4加上8微克/毫升苯唑西林（< MIC的1/4）的联合用药，在8小时时对9株分离株中的7株具有协同作用，尽管在24小时时未显示出显著协同作用。这种联合用药可能对多重耐药的耐甲氧西林金黄色葡萄球菌有效，值得进一步研究。
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