哌唑嗪治疗在伊拉克部署的士兵的创伤性噩梦和睡眠障碍。

Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq.

机构信息

Madigan Army Medical Center and VA Northwest Network Mental Illness, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108, USA.

出版信息

J Trauma Stress. 2010 Oct;23(5):645-8. doi: 10.1002/jts.20570.

DOI:10.1002/jts.20570

PMID:20931662

Abstract

Trauma nightmares and sleep disturbance impair combat soldiers' functioning. The alpha-1 adrenoreceptor antagonist prazosin has been demonstrated effective for these symptoms in Vietnam veterans. Thirteen soldiers seeking relief from distressing trauma nightmares impairing military function in northern Iraq in 2006 received prazosin alone or in combination with other psychotropics. Mean prazosin dose was 4.1 (SD = 2.2) mg before bed. Six soldiers improved markedly and 3 moderately on the Clinical Global Impression of Change Ratings of distressing dreams decreased from an average of 7.0 (SD = 0.7) to 2.9 (SD = 3.0, p < .001) and those of disturbed sleep from 6.7 (SD = 0.9) to 3.7 (SD = 2.4, p < .001). Prazosin appears effective and well tolerated in the desert warfare environment.

摘要

创伤后噩梦和睡眠障碍会影响作战士兵的功能。在越南退伍军人中，α-1 肾上腺素受体拮抗剂哌唑嗪已被证明对这些症状有效。2006 年，在伊拉克北部寻求缓解创伤后噩梦困扰、影响军事功能的 13 名士兵单独或联合使用哌唑嗪和其他精神药物。平均哌唑嗪剂量为睡前 4.1（SD=2.2）mg。6 名士兵的病情明显改善，3 名士兵的病情中度改善，痛苦梦境的临床总体印象变化评定从平均 7.0（SD=0.7）降至 2.9（SD=3.0，p<0.001），睡眠障碍从 6.7（SD=0.9）降至 3.7（SD=2.4，p<0.001）。哌唑嗪在沙漠作战环境中似乎有效且耐受良好。