睡眠不足的人类大脑。
The sleep-deprived human brain.
作者信息
Krause Adam J, Simon Eti Ben, Mander Bryce A, Greer Stephanie M, Saletin Jared M, Goldstein-Piekarski Andrea N, Walker Matthew P
机构信息
Department of Psychology, University of California, Berkeley.
Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-1650, USA.
出版信息
Nat Rev Neurosci. 2017 Jul;18(7):404-418. doi: 10.1038/nrn.2017.55. Epub 2017 May 18.
Abstract
How does a lack of sleep affect our brains? In contrast to the benefits of sleep, frameworks exploring the impact of sleep loss are relatively lacking. Importantly, the effects of sleep deprivation (SD) do not simply reflect the absence of sleep and the benefits attributed to it; rather, they reflect the consequences of several additional factors, including extended wakefulness. With a focus on neuroimaging studies, we review the consequences of SD on attention and working memory, positive and negative emotion, and hippocampal learning. We explore how this evidence informs our mechanistic understanding of the known changes in cognition and emotion associated with SD, and the insights it provides regarding clinical conditions associated with sleep disruption.
摘要
睡眠不足如何影响我们的大脑？与睡眠的益处形成对比的是，探讨睡眠缺失影响的框架相对较少。重要的是，睡眠剥夺（SD）的影响并不简单地反映睡眠的缺失及其带来的益处；相反，它们反映了包括长时间清醒在内的几个额外因素的后果。我们聚焦于神经影像学研究，回顾睡眠剥夺对注意力和工作记忆、积极和消极情绪以及海马体学习的影响。我们探究这些证据如何增进我们对与睡眠剥夺相关的已知认知和情绪变化的机制理解，以及它为与睡眠中断相关的临床状况提供了哪些见解。
相似文献
1
The sleep-deprived human brain.睡眠不足的人类大脑。
Nat Rev Neurosci. 2017 Jul;18(7):404-418. doi: 10.1038/nrn.2017.55. Epub 2017 May 18.
2
Effects of sleep deprivation on cognition.睡眠剥夺对认知的影响。
Prog Brain Res. 2010;185:105-29. doi: 10.1016/B978-0-444-53702-7.00007-5.
3
Emotional working memory during sustained wakefulness.持续清醒状态下的情绪工作记忆。
J Sleep Res. 2014 Dec;23(6):646-656. doi: 10.1111/jsr.12170. Epub 2014 Jun 6.
4
Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition.关于睡眠及睡眠剥夺如何影响记忆和认知的功能性神经影像学见解。
Curr Opin Neurol. 2008 Aug;21(4):417-23. doi: 10.1097/WCO.0b013e3283052cf7.
5
How acute total sleep loss affects the attending brain: a meta-analysis of neuroimaging studies.急性完全睡眠剥夺如何影响大脑：神经影像学研究的荟萃分析。
Sleep. 2015 Feb 1;38(2):233-40. doi: 10.5665/sleep.4404.
6
Could BDNF be involved in compensatory mechanisms to maintain cognitive performance despite acute sleep deprivation? An exploratory study.尽管存在急性睡眠剥夺，脑源性神经营养因子（BDNF）是否参与维持认知表现的代偿机制？一项探索性研究。
Int J Psychophysiol. 2016 Jan;99:96-102. doi: 10.1016/j.ijpsycho.2015.11.008. Epub 2015 Nov 19.
7
Total sleep deprivation reduces top-down regulation of emotion without altering bottom-up affective processing.完全睡眠剥夺减少了情绪的自上而下的调节，而不改变自下而上的情感加工。
PLoS One. 2021 Sep 2;16(9):e0256983. doi: 10.1371/journal.pone.0256983. eCollection 2021.
8
Effect of sleep deprivation on emotional working memory.睡眠剥夺对情绪工作记忆的影响。
J Sleep Res. 2019 Feb;28(1):e12744. doi: 10.1111/jsr.12744. Epub 2018 Aug 8.
9
Measurement of cognition in studies of sleep deprivation.睡眠剥夺研究中的认知测量。
Prog Brain Res. 2010;185:37-48. doi: 10.1016/B978-0-444-53702-7.00003-8.
10
Effects of sleep deprivation on prospective memory.睡眠剥夺对前瞻性记忆的影响。
Memory. 2014;22(6):679-86. doi: 10.1080/09658211.2013.812220. Epub 2013 Jul 26.
引用本文的文献
1
Single-Night Sleep Extension Enhances Morning Physical and Cognitive Performance Across Time of Day in Physically Active University Students: A Randomized Crossover Study.单次夜间睡眠延长可增强身体活跃的大学生一天中不同时间段的早晨身体和认知表现：一项随机交叉研究。
Life (Basel). 2025 Jul 24;15(8):1178. doi: 10.3390/life15081178.
2
Repercussions of sleep quality on the P300 auditory evoked potential in older adults.睡眠质量对老年人P300听觉诱发电位的影响。
Dement Neuropsychol. 2025 Aug 18;19:e20240271. doi: 10.1590/1980-5764-DN-2024-0271. eCollection 2025.
3
Regular sleep patterns, not just duration, critical for mental health: association of accelerometer-derived sleep regularity with incident depression and anxiety.规律的睡眠模式，而非仅仅睡眠时间，对心理健康至关重要：加速度计得出的睡眠规律与新发抑郁和焦虑的关联
Psychol Med. 2025 Aug 15;55:e239. doi: 10.1017/S0033291725101281.
4
Cortical activation and functional connectivity in patients with chronic insomnia based on working memory tasks: a multi-channel near-infrared spectroscopy study.基于工作记忆任务的慢性失眠患者的皮质激活与功能连接：一项多通道近红外光谱研究
BMC Psychiatry. 2025 Aug 14;25(1):788. doi: 10.1186/s12888-025-07177-5.
5
Exploring risk and protective urban environmental factors on mental health through exposure network mapping.通过暴露网络映射探索城市环境中影响心理健康的风险因素和保护因素。
Res Sq. 2025 Aug 6:rs.3.rs-7155816. doi: 10.21203/rs.3.rs-7155816/v1.
6
Neural correlates underlying state anxiety alterations following sleep deprivation: insights from frontal alpha asymmetry and phase-amplitude coupling.睡眠剥夺后状态焦虑改变的神经关联：来自额叶α波不对称性和相位-振幅耦合的见解
Front Psychol. 2025 Jul 11;16:1633875. doi: 10.3389/fpsyg.2025.1633875. eCollection 2025.
7
Effect of chronic sleep restriction on ethanol preference and cortical structural plasticity.长期睡眠限制对乙醇偏好和皮质结构可塑性的影响。
Neurobiol Sleep Circadian Rhythms. 2025 May 14;18(Suppl):100126. doi: 10.1016/j.nbscr.2025.100126. eCollection 2025 May.
8
The mediating role of sleep in PTSD and positive/negative emotional states during the COVID-19 resurgence.睡眠在新冠疫情复发期间创伤后应激障碍及正负性情绪状态中的中介作用
Sci Rep. 2025 Jul 21;15(1):26470. doi: 10.1038/s41598-025-11414-y.
9
The impact of 24-hour sleep deprivation on cognition and inflammatory response in anesthesiologists and nurses in operating rooms.24小时睡眠剥夺对手术室麻醉医生和护士认知及炎症反应的影响
Saudi J Anaesth. 2025 Jul-Sep;19(3):353-362. doi: 10.4103/sja.sja_772_24. Epub 2025 Jun 16.
10
COG1410 Alleviated Chronic Sleep Deprivation-Induced Memory Loss by Regulating Microglial Phagocytosis and Inhibiting Hippocampal Inflammation.COG1410通过调节小胶质细胞吞噬作用和抑制海马体炎症减轻慢性睡眠剥夺诱导的记忆丧失。
ACS Chem Neurosci. 2025 Aug 6;16(15):2921-2934. doi: 10.1021/acschemneuro.5c00214. Epub 2025 Jul 8.
本文引用的文献
1
Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction.睡眠剥夺会干扰对条件性恐惧消退的记忆。
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):123-129. doi: 10.1016/j.bpsc.2016.05.004.
2
Degradation of cortical representations during encoding following sleep deprivation.睡眠剥夺后编码过程中皮层表象的退化。
Neuroimage. 2017 Jun;153:131-138. doi: 10.1016/j.neuroimage.2017.01.080. Epub 2017 Feb 2.
3
Local modulation of human brain responses by circadian rhythmicity and sleep debt.昼夜节律和睡眠债对人脑反应的局部调节。
Science. 2016 Aug 12;353(6300):687-90. doi: 10.1126/science.aad2993.
4
A population study of the association between sleep disturbance and suicidal behaviour in people with mental illness.一项关于精神疾病患者睡眠障碍与自杀行为之间关联的人群研究。
J Psychiatr Res. 2016 Nov;82:149-54. doi: 10.1016/j.jpsychires.2016.07.025. Epub 2016 Jul 31.
5
Short-term memory deficits correlate with hippocampal-thalamic functional connectivity alterations following acute sleep restriction.短期记忆缺陷与急性睡眠限制后海马-丘脑功能连接改变相关。
Brain Imaging Behav. 2017 Aug;11(4):954-963. doi: 10.1007/s11682-016-9570-1.
6
Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?睡眠：阿尔茨海默病病理学中的一种新型机制途径、生物标志物及治疗靶点？
Trends Neurosci. 2016 Aug;39(8):552-566. doi: 10.1016/j.tins.2016.05.002. Epub 2016 Jun 17.
7
Partial sleep deprivation impacts impulsive action but not impulsive decision-making.部分睡眠剥夺会影响冲动行为，但不会影响冲动决策。
Physiol Behav. 2016 Oct 1;164(Pt A):214-9. doi: 10.1016/j.physbeh.2016.06.003. Epub 2016 Jun 4.
8
A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments.人类多巴胺转运体的基因多态性决定了睡眠剥夺对大脑对奖励和惩罚反应的影响。
J Cogn Neurosci. 2016 Jun;28(6):803-10. doi: 10.1162/jocn_a_00939. Epub 2016 Feb 26.
9
Human Hippocampal Structure: A Novel Biomarker Predicting Mnemonic Vulnerability to, and Recovery from, Sleep Deprivation.人类海马体结构：一种预测睡眠剥夺导致的记忆易损性及恢复情况的新型生物标志物。
J Neurosci. 2016 Feb 24;36(8):2355-63. doi: 10.1523/JNEUROSCI.3466-15.2016.
10
The brain functional connectome is robustly altered by lack of sleep.睡眠不足会显著改变大脑功能连接组。
Neuroimage. 2016 Feb 15;127:324-332. doi: 10.1016/j.neuroimage.2015.12.028. Epub 2015 Dec 19.
Zotero 插件