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[草本植物基因组计划的研究策略]

[Strategies of the study on herb genome program].

作者信息

Chen Shi-lin, Sun Yong-zhen, Xu Jiang, Luo Hong-mei, Sun Chao, He Liu, Cheng Xiang-lin, Zhang Bo-li, Xiao Pei-gen

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.

出版信息

Yao Xue Xue Bao. 2010 Jul;45(7):807-12.

Abstract

Herb Genome Program (HerbGP) includes a series of projects on whole genome sequencing (WGS) and post-genomics research of medicinal plants with unique secondary metabolism pathways or/and those of great medical and pharmaceutical importance. In this paper, we systematically discussed the strategy of HerbGP, from species selection, whole-genome sequencing, assembly and bioinformatics analysis, to postgenomics research. HerbGP will push study on Chinese traditional medicines into the front field of life science, by selecting a series of plants with unique secondary metabolism pathways as models and introducing "omics" methods into the research of these medicinal plants. HerbGP will provide great opportunities for China to be the leader in the basic research field of traditional Chinese medicine. HerbGP shall also have significant impacts on the R&D of natural medicines and the development of medicinal farming by analysis of secondary metabolic pathways and selection of cultivars with good agricultural traits.

摘要

药用植物基因组计划(HerbGP)包括一系列关于全基因组测序(WGS)以及对具有独特次生代谢途径或/和具有重大医学和药学重要性的药用植物进行后基因组学研究的项目。在本文中,我们系统地讨论了药用植物基因组计划的策略,从物种选择、全基因组测序、组装和生物信息学分析,到后基因组学研究。药用植物基因组计划将通过选择一系列具有独特次生代谢途径的植物作为模型,并将“组学”方法引入这些药用植物的研究中,推动中药研究进入生命科学前沿领域。药用植物基因组计划将为中国在中药基础研究领域成为领先者提供巨大机遇。通过分析次生代谢途径和选择具有良好农艺性状的品种,药用植物基因组计划还将对天然药物研发和药用种植业发展产生重大影响。

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