氯丙嗪增强吡柔比星对多柔比星耐药的P388白血病小鼠的抗肿瘤活性。
Potentiation of antitumor activity of pirarubicin by chlorpromazine in mice bearing doxorubicin-resistant P388 leukemia.
作者信息
Shibata H, Maekawa I, Furusawa S, Kawauchi H, Takayanagi Y, Sasaki K
机构信息
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
出版信息
Res Commun Chem Pathol Pharmacol. 1990 Dec;70(3):359-62.
PMID:2093213
Abstract
Chlorpromazine enhanced the cytotoxicity of pirarubicin against doxorubicin-resistant P388 leukemia cells in colony forming assays. Chlorpromazine also prolonged the survival of mice bearing doxorubicin-resistant P388 leukemia, when given in combination with pirarubicin.
摘要
在集落形成试验中，氯丙嗪增强了吡柔比星对多柔比星耐药的P388白血病细胞的细胞毒性。当与吡柔比星联合使用时，氯丙嗪还延长了携带多柔比星耐药P388白血病的小鼠的生存期。
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