Western Australian Centre for Health and Ageing (M570), Centre for Health Research, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
Aust N Z J Psychiatry. 2010 Oct;44(10):888-93. doi: 10.3109/00048674.2010.491816.
Although the prevalence of dementia in remote living Aboriginal Australians is one of the highest in the world, the factors associated with dementia in this population are yet to be examined. This study was designed to determine the demographic, lifestyle and clinical factors associated with dementia in Aboriginal Australians living in the Kimberley region of Western Australia.
A total of 363 Aboriginal Australians aged over 45 years from the Kimberley region were selected by semi-purposeful sampling. The factors analysed for association with dementia were age, sex, education, smoking, chewing tobacco, alcohol, head injury, heart disease, hypertension, diabetes, previous stroke, epilepsy, falls, mobility, incontinence, urinary problems, vision and hearing. This exposure data was collected from participants' and informants' reports using the Kimberley Indigenous Cognitive Assessment and specialist review, and medical records.
Factors associated with dementia included older age, male gender (OR 3.1, 95%CI 1.4, 6.8) and no formal education (OR 2.7, 95%CI 1.1, 6.7) and after adjusting for age, sex and education, dementia was associated with current smoking (OR 4.5, 95%CI 1.1, 18.6), previous stroke (OR 17.9, 95%CI 5.9, 49.7), epilepsy (OR 33.5, 95%CI 4.8, 232.3), head injury (OR 4.0, 95%CI 1.7, 9.4), and poor mobility, incontinence and falls.
Interventions aimed at better management or prevention of the modifiable factors identified could reduce dementia risk in Aboriginal populations.
尽管偏远地区生活的澳大利亚原住民中痴呆症的患病率是世界上最高的之一，但该人群中与痴呆症相关的因素尚未得到研究。本研究旨在确定居住在西澳大利亚金伯利地区的澳大利亚原住民中与痴呆症相关的人口统计学、生活方式和临床因素。
通过半目的抽样，从金伯利地区选择了 363 名年龄在 45 岁以上的澳大利亚原住民。分析与痴呆症相关的因素包括年龄、性别、教育、吸烟、嚼烟、饮酒、头部受伤、心脏病、高血压、糖尿病、既往中风、癫痫、跌倒、活动能力、失禁、尿失禁、视力和听力问题。这些暴露数据是通过金伯利土著认知评估和专家审查以及医疗记录，从参与者和知情人的报告中收集的。
与痴呆症相关的因素包括年龄较大、男性（OR 3.1，95%CI 1.4，6.8）和没有正规教育（OR 2.7，95%CI 1.1，6.7），在调整年龄、性别和教育后，痴呆症与当前吸烟（OR 4.5，95%CI 1.1，18.6）、既往中风（OR 17.9，95%CI 5.9，49.7）、癫痫（OR 33.5，95%CI 4.8，232.3）、头部受伤（OR 4.0，95%CI 1.7，9.4）以及活动能力差、失禁和跌倒有关。
针对可改变因素的更好管理或预防的干预措施可能会降低澳大利亚原住民的痴呆症风险。
