Department of Health Sciences, Gettysburg College, Gettysburg Pennsylvania, USA.
J Int Soc Sports Nutr. 2010 Oct 8;7:31. doi: 10.1186/1550-2783-7-31.
To determine the effects of supplemental fish oil (FO) on resting metabolic rate (RMR), body composition, and cortisol production in healthy adults.
A total of 44 men and women (34 ± 13y, mean+SD) participated in the study. All testing was performed first thing in the morning following an overnight fast. Baseline measurements of RMR were measured using indirect calorimetry using a facemask, and body composition was measured using air displacement plethysmography. Saliva was collected via passive drool and analyzed for cortisol concentration using ELISA. Following baseline testing, subjects were randomly assigned in a double blind manner to one of two groups: 4 g/d of Safflower Oil (SO); or 4 g/d of FO supplying 1,600 mg/d eicosapentaenoic acid (EPA) and 800 mg/d docosahexaenoic acid (DHA). All tests were repeated following 6 wk of treatment. Pre to post differences were analyzed using a treatment X time repeated measures ANOVA, and correlations were analyzed using Pearson's r.
Compared to the SO group, there was a significant increase in fat free mass following treatment with FO (FO = +0.5 ± 0.5 kg, SO = -0.1 ± 1.2 kg, p = 0.03), a significant reduction in fat mass (FO = -0.5 ± 1.3 kg, SO = +0.2 ± 1.2 kg, p = 0.04), and a tendency for a decrease in body fat percentage (FO = -0.4 ± 1.3% body fat, SO = +0. 3 ± 1.5% body fat, p = 0.08). No significant differences were observed for body mass (FO = 0.0 ± 0.9 kg, SO = +0.2 ± 0.8 kg), RMR (FO = +17 ± 260 kcal, SO = -62 ± 184 kcal) or respiratory exchange ratio (FO = -0.02 ± 0.09, SO = +0.02 ± 0.05). There was a tendency for salivary cortisol to decrease in the FO group (FO = -0.064 ± 0.142 μg/dL, SO = +0.016 ± 0.272 μg/dL, p = 0.11). There was a significant correlation in the FO group between change in cortisol and change in fat free mass (r = -0.504, p = 0.02) and fat mass (r = 0.661, p = 0.001).
6 wk of supplementation with FO significantly increased lean mass and decreased fat mass. These changes were significantly correlated with a reduction in salivary cortisol following FO treatment.
为了确定补充鱼油（FO）对健康成年人静息代谢率（RMR）、身体成分和皮质醇产生的影响。
共有 44 名男性和女性（34 ± 13 岁，均值+标准差）参与了这项研究。所有测试均在禁食过夜后的清晨第一时间进行。使用面罩通过间接测热法测量 RMR 的基线测量值，并使用空气置换体描记法测量身体成分。通过被动流涎收集唾液，并使用 ELISA 分析皮质醇浓度。在基线测试后，将受试者以双盲方式随机分配到两组之一：每天 4 克红花油（SO）；或每天 4 克 FO，提供 1600 毫克/天二十碳五烯酸（EPA）和 800 毫克/天二十二碳六烯酸（DHA）。在治疗 6 周后重复所有测试。使用治疗 X 时间重复测量 ANOVA 分析预处理和后处理之间的差异，并使用 Pearson r 分析相关性。
与 SO 组相比，FO 治疗后瘦体重显著增加（FO = +0.5 ± 0.5 公斤，SO = -0.1 ± 1.2 公斤，p = 0.03），脂肪量显著减少（FO = -0.5 ± 1.3 公斤，SO = +0.2 ± 1.2 公斤，p = 0.04），体脂百分比呈下降趋势（FO = -0.4 ± 1.3%体脂，SO = +0.3 ± 1.5%体脂，p = 0.08）。体重（FO = 0.0 ± 0.9 公斤，SO = +0.2 ± 0.8 公斤）、RMR（FO = +17 ± 260 千卡，SO = -62 ± 184 千卡）或呼吸交换率（FO = -0.02 ± 0.09，SO = +0.02 ± 0.05）无显著差异。FO 组唾液皮质醇有下降趋势（FO = -0.064 ± 0.142 μg/dL，SO = +0.016 ± 0.272 μg/dL，p = 0.11）。FO 组皮质醇变化与瘦体重变化呈显著正相关（r = -0.504，p = 0.02），与脂肪量变化呈显著正相关（r = 0.661，p = 0.001）。
6 周补充 FO 可显著增加瘦体重并减少脂肪量。这些变化与 FO 治疗后唾液皮质醇的降低显著相关。
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