Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation.
作者信息
Sun Albert Y, Pitt Geoffrey S
机构信息
Ion Channel Research Unit, Division of Cardiovascular Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Heart Rhythm. 2011 Apr;8(4):631-3. doi: 10.1016/j.hrthm.2010.10.001. Epub 2010 Oct 7.
Abstract
摘要
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Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation.
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Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570.小鼠心脏L型Ca(v)1.2通道的易化作用受钙调蛋白激酶II依赖的S1512和S1570磷酸化调节。
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beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.β肾上腺素能受体刺激后β-arrestin 依赖性的 Ca(2+)/钙调蛋白激酶 II 的激活。
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CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations.CaV1.2β亚基协调 CaMKII 触发的心肌细胞死亡和后除极。
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