一种新的天然螺环杂环化合物和柏科植物短叶圆柏叶次生代谢物的细胞毒性活性。
A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves.
机构信息
Department of Microbiology and Cell Biology, and Canary Islands Cancer Research Institute, University of La Laguna, La Laguna, Tenerife, Spain.
出版信息
Fitoterapia. 2011 Mar;82(2):225-9. doi: 10.1016/j.fitote.2010.10.001. Epub 2010 Oct 8.
A new natural spiro compound 3,4-dehydrotheaspirone and the known arctiol [1β,6α-dihydroxy-4(14)-eudesmene] were isolated from Juniperus brevifolia. Arctiol is reported for the first time in the Juniperus genus. Their structures were established by 1D, and 2D NMR and MS spectra. Antimicrobial and cytotoxic activities of 1 and several secondary metabolites 3,4,5,6,7,8,9,10,11,12 previously isolated by our group from J. brevifolia were evaluated and some SAR has been established. The 18-hydroxydehydroabietane (4) displayed great antiproliferative activity against cancer cell lines tested, namely HeLa, A-549 and MCF-7. Compound 4 also presented a significant bactericidal effect against Bacillus cereus at different concentrations tested.
从短叶松中分离得到一种新的天然螺环化合物 3,4-去氢雪松酮和已知的 arctiol [1β,6α-二羟基-4(14)-葎草烯]。Arctiol 是首次在 Juniperus 属中发现的。通过 1D 和 2D NMR 和 MS 光谱确定了它们的结构。评估了我们之前从短叶松中分离得到的 1 号化合物和几种次级代谢物 3,4,5,6,7,8,9,10,11,12 的抗菌和细胞毒性活性，并建立了一些 SAR。18-羟基去氢枞酸（4）对测试的癌细胞系（HeLa、A-549 和 MCF-7）表现出很强的抗增殖活性。化合物 4 在不同浓度下对蜡样芽孢杆菌也表现出显著的杀菌作用。
Zotero 插件