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眶压计血流与血栓形成。

Orbitometer flow and thrombus formation.

作者信息

Hartert H

出版信息

Biorheology. 1990;27(6):921-9. doi: 10.3233/bir-1990-27613.

DOI:10.3233/bir-1990-27613
PMID:2093400
Abstract

Orbitometry (Hartert) is a rheological ex-vivo method to follow up physical assembly of a coagulum in layers during natural intensity of flow by orbital movement. Fibrin elasticity in the Orbitometers mode of Resonance Thrombography is differentiated from platelet activity as well as e.g. from the effects of disseminated coagulation-minimal in liver disease and maximal during disturbances of delivery. Transition into the mode of dynamic Tendography (Hartert) will e.g. register all fast going tests lasting minutes or seconds. It is comparable to an accelerated form of Thrombelastography (Hartert), the intercourse of which with coagulum yet is an exclusively static operation. Another category is measurement of blood and plasma viscosity. In concentrated blood it seizes plasticity of blood cells as well as their intensity of aggregation in orbital flow. The latest methodical development of Orbitometry is control of platelet activity in its function of adhesion. This is realized by measurement of specific physical effects released in platelet containing coagulum. They generate a structural degradation of fibrin elasticity modul as well as a tendency for coagulum adhesion. The practical use of Adhesiography is control of anticoagulants and platelet protecting substances in their quantitative influence on coagulum structure and on the mentioned platelet activities. A special disturbance of these platelet depending mechnisms obviously is getting evidence in case of v. Willebrand's syndrome.

摘要

眼眶测量法(哈特尔特法)是一种流变学生物体外方法,用于在自然流动强度下通过眼眶运动追踪血凝块分层的物理组装过程。共振血栓形成法眼眶测量仪模式下的纤维蛋白弹性与血小板活性不同,例如与弥漫性凝血的影响不同——在肝病中最小,在分娩紊乱时最大。转换到动态腱描记法(哈特尔特法)模式,例如将记录所有持续数分钟或数秒的快速测试。它类似于血栓弹力图(哈特尔特法)的加速形式,但其与血凝块的相互作用完全是静态操作。另一类是血液和血浆粘度的测量。在浓缩血液中,它捕捉血细胞的可塑性及其在眼眶流动中的聚集强度。眼眶测量法的最新方法进展是控制血小板在其黏附功能中的活性。这是通过测量含血小板血凝块中释放的特定物理效应来实现的。它们会导致纤维蛋白弹性模量的结构降解以及血凝块黏附的趋势。黏附描记法的实际用途是控制抗凝剂和血小板保护物质对血凝块结构和上述血小板活性的定量影响。在血管性血友病综合征的情况下,这些依赖血小板的机制会出现特殊紊乱,这一点很明显。

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