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共振血栓成像术

Resonance thrombography.

作者信息

Hartert H

出版信息

Biorheology Suppl. 1984;1:15-22. doi: 10.3233/bir-1984-23s104.

DOI:10.3233/bir-1984-23s104
PMID:6591968
Abstract

Resonance Thrombography is a method to follow up the coagulation process ex vivo from its very beginning up to its final consolidation phase resp. fibrinolysis. The mode of measurement is adopting the resonance effect of fibrin elasticity. The connection of a cylindric rod and outer cylinder by elastic fibrin fibres will increase the potential natural frequency (38 Hz) of the elastically suspended rod, to which a constant orbital drive of a very small radius is imported electronically. Change of difference between constant drive frequency and varying resonance frequency over time will result in sensitive registration of the Resonance Thrombogram (RTG). The orbital movement of the rod causes a circular flow of blood as long as it is fluid. The speed of flow is comparable to that in a medium sized vein, resembling a physiological situation. The clinical application of RTGraphy is regarding the fact, that there is practically no disturbance of clotting process which is not represented in any change of clot construction. Diagnosis of DIC, demonstration of SFMC as well as of fibrinolysis, differentiation between the effect of fibrin structure and of platelet activity are among the clinical assignments of RTGraphy.

摘要

共振血栓形成术是一种在体外从凝血过程开始直至最终巩固阶段(即纤维蛋白溶解阶段)对其进行跟踪的方法。测量方式是利用纤维蛋白弹性的共振效应。弹性纤维蛋白将圆柱杆与外圆柱连接起来,会增加弹性悬挂杆的固有频率(38赫兹),通过电子方式向其输入一个半径非常小的恒定圆周驱动力。恒定驱动频率与变化的共振频率之间的差值随时间的变化,将导致对共振血栓图(RTG)进行灵敏记录。只要血液是流体状态,杆的圆周运动会使血液形成环形流动。血流速度与中等大小静脉中的血流速度相当,类似于生理状态。共振血栓形成术的临床应用基于这样一个事实,即凝血过程中几乎没有任何干扰不会在血凝块结构的任何变化中体现出来。弥漫性血管内凝血的诊断、可溶性纤维蛋白单体复合物(SFMC)以及纤维蛋白溶解的显示、纤维蛋白结构效应与血小板活性之间的区分,都属于共振血栓形成术的临床应用范畴。

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