细胞死亡与行为的性分化：蠕虫、苍蝇和哺乳动物。
Cell death and sexual differentiation of behavior: worms, flies, and mammals.
机构信息
Department of Psychology and Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA.
出版信息
Curr Opin Neurobiol. 2010 Dec;20(6):776-83. doi: 10.1016/j.conb.2010.09.006. Epub 2010 Oct 8.
Abstract
Sex differences in the nervous system are found throughout the animal kingdom. Here, we discuss three prominent genetic models: nematodes, fruit flies, and mice. In all three, differential cell death is central to sexual differentiation and shared molecular mechanisms have been identified. Our knowledge of the precise function of neural sex differences lags behind. One fruitful approach to the 'function' question is to contrast sexual differentiation in standard laboratory animals with differentiation in species exhibiting unique social and reproductive organizations. Advanced genetic strategies are also addressing this question in worms and flies, and may soon be applicable to vertebrates.
摘要
在整个动物王国中都存在神经系统的性别差异。在这里，我们讨论了三个突出的遗传模型：线虫、果蝇和老鼠。在这三种模型中，细胞死亡的差异是性分化的核心，已确定存在共享的分子机制。我们对神经性别差异的确切功能的了解还远远落后。解决“功能”问题的一个富有成效的方法是将标准实验室动物的性分化与具有独特社会和生殖组织的物种的分化进行对比。先进的遗传策略也在解决线虫和果蝇中的这个问题，并且可能很快适用于脊椎动物。
相似文献
1
Cell death and sexual differentiation of behavior: worms, flies, and mammals.细胞死亡与行为的性分化：蠕虫、苍蝇和哺乳动物。
Curr Opin Neurobiol. 2010 Dec;20(6):776-83. doi: 10.1016/j.conb.2010.09.006. Epub 2010 Oct 8.
2
The worm returns.蠕虫回来了。
Nature. 2015 Oct 15;526(7573):294. doi: 10.1038/526294a.
3
Neural Circuits of Sexual Behavior in Caenorhabditis elegans.秀丽隐杆线虫性行为的神经回路。
Annu Rev Neurosci. 2018 Jul 8;41:349-369. doi: 10.1146/annurev-neuro-070815-014056. Epub 2018 Apr 25.
4
Molecular Mechanisms of Sexually Dimorphic Nervous System Patterning in Flies and Worms.果蝇和线虫中性别二态性神经系统模式形成的分子机制。
Annu Rev Cell Dev Biol. 2021 Oct 6;37:519-547. doi: 10.1146/annurev-cellbio-120319-115237.
5
Sexual Dimorphism and Sex Differences in Neuronal Development and Behavior.性二态性和性别差异在神经元发育和行为中的表现。
Genetics. 2018 Mar;208(3):909-935. doi: 10.1534/genetics.117.300294.
6
Neural circuits for sexually dimorphic and sexually divergent behaviors in Caenorhabditis elegans.秀丽隐杆线虫中性别二态性和性别差异行为的神经回路。
Curr Opin Neurobiol. 2016 Jun;38:46-52. doi: 10.1016/j.conb.2016.02.002. Epub 2016 Mar 3.
7
The development of sex differences in the nervous system and behavior of flies, worms, and rodents.神经系统和行为的性别差异在果蝇、线虫和啮齿类动物中的发展。
Dev Biol. 2021 Apr;472:75-84. doi: 10.1016/j.ydbio.2021.01.010. Epub 2021 Jan 20.
8
Sexual modulation of neural circuits and behavior in Caenorhabditis elegans.线虫中神经回路和行为的性调节。
Semin Cell Dev Biol. 2014 Sep;33:3-9. doi: 10.1016/j.semcdb.2014.06.007. Epub 2014 Jun 14.
9
Molecular neurogenetics of sexual differentiation and behaviour.性别分化与行为的分子神经遗传学
Curr Opin Neurobiol. 1999 Dec;9(6):759-65. doi: 10.1016/s0959-4388(99)00030-6.
10
Sexual modulation of sex-shared neurons and circuits in Caenorhabditis elegans.秀丽隐杆线虫中性别共享神经元和神经回路的性别调节
J Neurosci Res. 2017 Jan 2;95(1-2):527-538. doi: 10.1002/jnr.23912.
引用本文的文献
1
Androgenic regulation of sexually dimorphic expression of RNA binding motif protein 48 in the developing mouse cortex and hippocampus.雄激素对发育中小鼠皮层和海马体中RNA结合基序蛋白48性别二态性表达的调控。
Int J Dev Neurosci. 2019 Nov;78:33-44. doi: 10.1016/j.ijdevneu.2019.07.011. Epub 2019 Aug 7.
2
Sex differences in avoidance behavior after perceiving potential risk in mice.雌雄小鼠感知潜在风险后回避行为的性别差异。
Behav Brain Funct. 2017 May 5;13(1):9. doi: 10.1186/s12993-017-0126-3.
3
Hypothalamic control of the male neonatal testosterone surge.下丘脑对雄性新生儿睾酮激增的控制。
Philos Trans R Soc Lond B Biol Sci. 2016 Feb 19;371(1688):20150115. doi: 10.1098/rstb.2015.0115. Epub 2016 Feb 1.
4
Sex differences and rapid estrogen signaling: A look at songbird audition.性别差异与雌激素快速信号传导：鸟类听觉研究
Front Neuroendocrinol. 2015 Jul;38:37-49. doi: 10.1016/j.yfrne.2015.01.001. Epub 2015 Jan 28.
5
Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling.大脑的性别分化需要围产期 kisspeptin-GnRH 神经元信号传导。
J Neurosci. 2014 Nov 12;34(46):15297-305. doi: 10.1523/JNEUROSCI.3061-14.2014.
6
Sex-specific processing of social cues in the medial amygdala.内侧杏仁核中社会线索的性别特异性处理。
Elife. 2014 Jun 3;3:e02743. doi: 10.7554/eLife.02743.
7
Representing sex in the brain, one module at a time.一次一个模块，代表大脑中的性别。
Neuron. 2014 Apr 16;82(2):261-78. doi: 10.1016/j.neuron.2014.03.029.
8
Sex determination strategies in 2012: towards a common regulatory model?2012 年的性别决定策略：走向共同的监管模式？
Reprod Biol Endocrinol. 2012 Feb 22;10:13. doi: 10.1186/1477-7827-10-13.
本文引用的文献
1
The structure of the nervous system of the nematode Caenorhabditis elegans.秀丽隐杆线虫的神经系统结构。
Philos Trans R Soc Lond B Biol Sci. 1986 Nov 12;314(1165):1-340. doi: 10.1098/rstb.1986.0056.
2
BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice.BAX 依赖性和非依赖性调节小鼠 Kiss1 神经元发育。
Endocrinology. 2010 Dec;151(12):5807-17. doi: 10.1210/en.2010-0783. Epub 2010 Oct 6.
3
Social status regulates kisspeptin receptor mRNA in the brain of Astatotilapia burtoni.社会地位调节伯氏丽鱼脑中的 kisspeptin 受体 mRNA。
Gen Comp Endocrinol. 2010 Oct;169(1):98-107. doi: 10.1016/j.ygcen.2010.07.018. Epub 2010 Aug 3.
4
Reproductive status regulates expression of sex steroid and GnRH receptors in the olfactory bulb.生殖状态调节嗅球中性类固醇和促性腺激素释放激素受体的表达。
Behav Brain Res. 2010 Dec 1;213(2):208-17. doi: 10.1016/j.bbr.2010.04.058. Epub 2010 May 11.
5
The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors.雄激素受体调控雄性性行为和领地行为的执行，但不调控其编程。
Neuron. 2010 Apr 29;66(2):260-72. doi: 10.1016/j.neuron.2010.03.024.
6
Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster.双性基因在果蝇中的性分化和行为控制。
Nat Neurosci. 2010 Apr;13(4):458-66. doi: 10.1038/nn.2515. Epub 2010 Mar 21.
7
Social structure predicts genital morphology in African mole-rats.社会结构预测非洲鼹形鼠的生殖器形态。
PLoS One. 2009 Oct 15;4(10):e7477. doi: 10.1371/journal.pone.0007477.
8
Central role of TRAF-interacting protein in a new model of brain sexual differentiation.TRAF相互作用蛋白在脑性别分化新模型中的核心作用
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16692-7. doi: 10.1073/pnas.0906293106. Epub 2009 Sep 17.
9
Estrogen induces caspase-dependent cell death during hypothalamic development.雌激素在下丘脑发育过程中诱导依赖半胱天冬酶的细胞死亡。
J Neurosci. 2009 Aug 5;29(31):9714-8. doi: 10.1523/JNEUROSCI.0135-09.2009.
10
Sex differences in the brain: the relation between structure and function.大脑中的性别差异：结构与功能之间的关系。
Horm Behav. 2009 May;55(5):589-96. doi: 10.1016/j.yhbeh.2009.03.012.
Zotero 插件