• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

内侧杏仁核中社会线索的性别特异性处理。

Sex-specific processing of social cues in the medial amygdala.

作者信息

Bergan Joseph F, Ben-Shaul Yoram, Dulac Catherine

机构信息

Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, United States.

School of Medicine, Department of Medical Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel.

出版信息

Elife. 2014 Jun 3;3:e02743. doi: 10.7554/eLife.02743.

DOI:10.7554/eLife.02743
PMID:24894465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4038839/
Abstract

Animal-animal recognition within, and across species, is essential for predator avoidance and social interactions. Despite its essential role in orchestrating responses to animal cues, basic principles of information processing by the vomeronasal system are still unknown. The medial amygdala (MeA) occupies a central position in the vomeronasal pathway, upstream of hypothalamic centers dedicated to defensive and social responses. We have characterized sensory responses in the mouse MeA and uncovered emergent properties that shed new light onto the transformation of vomeronasal information into sex- and species-specific responses. In particular, we show that the MeA displays a degree of stimulus selectivity and a striking sexually dimorphic sensory representation that are not observed in the upstream relay of the accessory olfactory bulb (AOB). Furthermore, our results demonstrate that the development of sexually dimorphic circuits in the MeA requires steroid signaling near the time of puberty to organize the functional representation of sensory stimuli.DOI: http://dx.doi.org/10.7554/eLife.02743.001.

摘要

在物种内部以及跨物种的动物间识别，对于躲避捕食者和社会互动至关重要。尽管犁鼻系统在协调对动物线索的反应中起着关键作用，但其信息处理的基本原理仍不为人知。内侧杏仁核（MeA）在犁鼻通路中占据中心位置，位于专门负责防御和社会反应的下丘脑中心的上游。我们已对小鼠MeA中的感觉反应进行了特征描述，并发现了一些新特性，这些特性为犁鼻信息转化为性别和物种特异性反应提供了新的线索。特别是，我们发现MeA表现出一定程度的刺激选择性以及显著的性别二态性感觉表征，而在副嗅球（AOB）的上游中继中并未观察到这些现象。此外，我们的结果表明，MeA中性别二态性回路的发育需要在青春期前后的类固醇信号来组织感觉刺激的功能表征。DOI: http://dx.doi.org/10.7554/eLife.02743.001

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/49dfab17913e/elife02743f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/905a4334ad0e/elife02743f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/3414219fd646/elife02743fs001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/7e8b46149fad/elife02743fs002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/c31827968458/elife02743fs003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/826a2de060e2/elife02743f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/b3a9b807bd0a/elife02743fs004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/34e908de70e2/elife02743fs005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/dd891444aa4f/elife02743f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/f472e0f7cdf2/elife02743fs006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/805a9d748163/elife02743fs007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/7219939c1ae9/elife02743f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/eafb348618da/elife02743fs008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/ba4a0a8326af/elife02743f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/49dfab17913e/elife02743f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/905a4334ad0e/elife02743f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/3414219fd646/elife02743fs001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/7e8b46149fad/elife02743fs002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/c31827968458/elife02743fs003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/826a2de060e2/elife02743f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/b3a9b807bd0a/elife02743fs004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/34e908de70e2/elife02743fs005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/dd891444aa4f/elife02743f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/f472e0f7cdf2/elife02743fs006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/805a9d748163/elife02743fs007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/7219939c1ae9/elife02743f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/eafb348618da/elife02743fs008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/ba4a0a8326af/elife02743f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777c/4038839/49dfab17913e/elife02743f006.jpg

相似文献

1
Sex-specific processing of social cues in the medial amygdala.内侧杏仁核中社会线索的性别特异性处理。
Elife. 2014 Jun 3;3:e02743. doi: 10.7554/eLife.02743.
2
A direct main olfactory bulb projection to the 'vomeronasal' amygdala in female mice selectively responds to volatile pheromones from males.雌性小鼠中从主嗅球到“犁鼻器”杏仁核的直接投射会选择性地对来自雄性的挥发性信息素作出反应。
Eur J Neurosci. 2009 Feb;29(3):624-34. doi: 10.1111/j.1460-9568.2009.06638.x. Epub 2009 Jan 28.
3
In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb.体内犁鼻器刺激揭示了小鼠副嗅球对同种和异种线索的感觉编码。
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5172-7. doi: 10.1073/pnas.0915147107. Epub 2010 Mar 1.
4
A centrifugal pathway to the mouse accessory olfactory bulb from the medial amygdala conveys gender-specific volatile pheromonal signals.从内侧杏仁核到小鼠副嗅球的一条离心通路传递性别特异性挥发性信息素信号。
Eur J Neurosci. 2009 Jan;29(2):368-76. doi: 10.1111/j.1460-9568.2008.06564.x. Epub 2008 Dec 11.
5
Synchronized Activity in The Main and Accessory Olfactory Bulbs and Vomeronasal Amygdala Elicited by Chemical Signals in Freely Behaving Mice.自由活动的小鼠嗅探化学信号时主嗅球和副嗅球及犁鼻器杏仁核中的同步活动。
Sci Rep. 2017 Aug 30;7(1):9924. doi: 10.1038/s41598-017-10089-4.
6
Functional dichotomy within the vomeronasal system: distinct zones of neuronal activity in the accessory olfactory bulb correlate with sex-specific behaviors.犁鼻系统内的功能二分法：副嗅球中不同的神经元活动区域与性别特异性行为相关。
J Neurosci. 1999 Oct 15;19(20):RC32. doi: 10.1523/JNEUROSCI.19-20-j0003.1999.
7
Both olfactory epithelial and vomeronasal inputs are essential for activation of the medial amygdala and preoptic neurons of male rats.嗅上皮和犁鼻器传入对于雄性大鼠内侧杏仁核和视前神经元的激活都是必需的。
Neuroscience. 2011 Dec 29;199:225-34. doi: 10.1016/j.neuroscience.2011.09.051. Epub 2011 Oct 1.
8
A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice.嗅球中的 GnRH 神经元群将与社会相关的气味转化为雄性小鼠的生殖行为。
Nat Neurosci. 2024 Sep;27(9):1758-1773. doi: 10.1038/s41593-024-01724-1. Epub 2024 Aug 2.
9
A sex-specific feedback projection from aromatase-expressing neurons in the medial amygdala to the accessory olfactory bulb.中杏仁核中表达芳香酶的神经元向副嗅球的性别特异性反馈投射。
J Comp Neurol. 2022 Feb;530(3):648-655. doi: 10.1002/cne.25236. Epub 2021 Aug 27.
10
Temporal Response Properties of Accessory Olfactory Bulb Neurons: Limitations and Opportunities for Decoding.嗅球辅助神经元的时间响应特性：解码的局限性和机遇。
J Neurosci. 2018 May 23;38(21):4957-4976. doi: 10.1523/JNEUROSCI.2091-17.2018. Epub 2018 Apr 30.

引用本文的文献

1
Exposure to acute psychological trauma prior to blast neurotrauma results in alternative behavioral outcomes.在爆炸性神经创伤之前遭受急性心理创伤会导致不同的行为结果。
eNeuro. 2025 Mar 17;12(3). doi: 10.1523/ENEURO.0026-24.2025.
2
The microbiome as a modulator of neurological health across the maternal-offspring interface.微生物群作为母婴界面神经健康的调节因子。
J Clin Invest. 2025 Feb 17;135(4):e184314. doi: 10.1172/JCI184314.
3
Development and function of the medial amygdala.内侧杏仁核的发育与功能。

本文引用的文献

1
Broadly tuned and respiration-independent inhibition in the olfactory bulb of awake mice.清醒小鼠嗅球中广泛调谐且与呼吸无关的抑制作用。
Nat Neurosci. 2014 Apr;17(4):569-76. doi: 10.1038/nn.3669. Epub 2014 Mar 2.
2
Heterogeneous electrophysiological and morphological properties of neurons in the mouse medial amygdala in vitro.体外培养的小鼠杏仁中央核神经元的异质性电生理和形态特性。
Brain Res. 2012 Oct 22;1480:41-52. doi: 10.1016/j.brainres.2012.08.050. Epub 2012 Aug 31.
3
Sensation in a single neuron pair represses male behavior in hermaphrodites.
Trends Neurosci. 2025 Jan;48(1):22-32. doi: 10.1016/j.tins.2024.11.004. Epub 2024 Dec 12.
4
Estrogen Receptor Alpha-Expressing Neurons in Bed Nucleus of the Stria Terminalis and Hypothalamus Encoding Aggression and Mating.终纹床核和下丘脑表达雌激素受体α的神经元编码攻击行为和交配行为。
eNeuro. 2024 Nov 26;11(11). doi: 10.1523/ENEURO.0218-24.2024. Print 2024 Nov.
5
Developmental Shifts in Amygdala Function.杏仁核功能的发育转变
Curr Top Behav Neurosci. 2024 Nov 16. doi: 10.1007/7854_2024_538.
6
Interconnected neural circuits mediating social reward.介导社会奖赏的相互连接的神经回路。
Trends Neurosci. 2024 Dec;47(12):1041-1054. doi: 10.1016/j.tins.2024.10.004. Epub 2024 Nov 11.
7
Hippocampal contextualization of social rewards in mice.小鼠中海马体对社会奖励的情境化处理。
Nat Commun. 2024 Nov 3;15(1):9493. doi: 10.1038/s41467-024-53866-2.
8
Auditory pallial regulation of the social behavior network.听觉脑皮层对社会行为网络的调节。
Commun Biol. 2024 Oct 16;7(1):1336. doi: 10.1038/s42003-024-07013-8.
9
Prior Negative Experience Biases Activity of Medial Amygdala during Interstrain Social Engagement in Male Rats.先前的负面经验会影响雄性大鼠在不同品系社交接触期间内侧杏仁核的活动。
eNeuro. 2024 Sep 23;11(9). doi: 10.1523/ENEURO.0288-24.2024. Print 2024 Sep.
10
Feminization of social play behavior depends on microglia.社交玩耍行为的雌性化依赖于小胶质细胞。
bioRxiv. 2024 Aug 19:2024.08.19.608675. doi: 10.1101/2024.08.19.608675.
单个神经元对的感觉抑制雌雄同体的雄性行为。
Neuron. 2012 Aug 23;75(4):593-600. doi: 10.1016/j.neuron.2012.03.044.
4
Calcium-activated sustained firing responses distinguish accessory from main olfactory bulb mitral cells.钙激活持续放电反应可区分副嗅球和主嗅球的僧帽细胞。
J Neurosci. 2012 May 2;32(18):6251-62. doi: 10.1523/JNEUROSCI.4397-11.2012.
5
Organization of vomeronasal sensory coding revealed by fast volumetric calcium imaging.快速容积钙成像揭示的犁鼻器感觉编码组织。
J Neurosci. 2012 Feb 1;32(5):1612-21. doi: 10.1523/JNEUROSCI.5339-11.2012.
6
Molecular organization of vomeronasal chemoreception.嗅球化学感觉的分子组织。
Nature. 2011 Sep 21;478(7368):241-5. doi: 10.1038/nature10437.
7
Distinct representations of olfactory information in different cortical centres.不同皮质中枢对嗅觉信息的不同表现形式。
Nature. 2011 Apr 14;472(7342):213-6. doi: 10.1038/nature09868. Epub 2011 Mar 30.
8
Associative cortex features in the first olfactory brain relay station.第一嗅觉脑中继站的联合皮层特征。
Neuron. 2011 Mar 24;69(6):1176-87. doi: 10.1016/j.neuron.2011.02.024.
9
Functional identification of an aggression locus in the mouse hypothalamus.在小鼠下丘脑鉴定出一个攻击相关基因座。
Nature. 2011 Feb 10;470(7333):221-6. doi: 10.1038/nature09736.
10
Cortical representations of olfactory input by trans-synaptic tracing.嗅传入的皮质代表通过突触追踪。
Nature. 2011 Apr 14;472(7342):191-6. doi: 10.1038/nature09714. Epub 2010 Dec 22.