Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Curr Opin Microbiol. 2011 Feb;14(1):16-23. doi: 10.1016/j.mib.2010.08.014. Epub 2010 Oct 8.
Although the intestinal epithelium is equipped with multiple defense systems that sense bacterial components, transmit alarms to the immune system, clear the bacteria, and renew the injured epithelial lining, mucosal bacterial pathogens are capable of efficiently colonizing the intestinal epithelium, because they have evolved systems that modulate the inflammatory and immune responses of the host and exploit the harmful environments as replicative niches. In this review we highlight current topics concerning Shigella's tactics that interfere with the innate immune systems.
尽管肠道上皮细胞配备了多种感知细菌成分的防御系统，向免疫系统发出警报，清除细菌并更新受损的上皮衬里，但粘膜细菌病原体能够有效地定植在肠道上皮细胞上，因为它们已经进化出了调节宿主炎症和免疫反应的系统，并利用有害环境作为复制小生境。在这篇综述中，我们强调了当前与志贺氏菌干扰固有免疫系统的策略相关的主题。
