Department of Neurology, Third Affiliated Hospital of Anhui Medical University, Huaihe Road 390, Hefei 230061, Anhui Province, China.
Behav Brain Res. 2011 Aug 10;221(2):587-93. doi: 10.1016/j.bbr.2010.09.031. Epub 2010 Oct 8.
Recent works have suggested an association between the ventromedial prefrontal cortex (VMPC) and social cognition or decision making. The aim of this study is to investigate the theory of mind and decision making in patients with VMPC lesions and in those with dorsolateral prefrontal cortex (DLPC) lesions. Patients with VMPC lesions (n=16) and those with DLPC lesions (n=14) were compared with healthy controls (HC) on faux pas recognition and 2 decision-making tasks. Consistent with previous data, patients with VMPC lesions performed worse on the theory of mind and decision making. Patients with DLPC lesions showed impairments of the theory of mind but performed at control levels on the 2 decision-making tasks. The results supported the view that a separation of function of 2 distinct subregions of the prefrontal cortex is important to the theory of mind and decision making.
最近的研究表明，腹内侧前额叶皮层（VMPC）与社会认知或决策之间存在关联。本研究旨在调查 VMPC 损伤患者和背外侧前额叶皮层（DLPC）损伤患者的心理理论和决策能力。将 VMPC 损伤患者（n=16）和 DLPC 损伤患者（n=14）与健康对照组（HC）进行比较，评估他们在识别失态和 2 项决策任务中的表现。与先前的数据一致，VMPC 损伤患者在心理理论和决策方面表现较差。DLPC 损伤患者表现出心理理论方面的损伤，但在 2 项决策任务中的表现与对照组相当。研究结果支持了这样一种观点，即前额叶皮层两个不同亚区的功能分离对心理理论和决策至关重要。
