Division of Allergy & Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Ann Allergy Asthma Immunol. 2010 Oct;105(4):295-8. doi: 10.1016/j.anai.2010.07.009.
The International Union of Immunological Societies defined transient hypogammaglobulinemia of infancy as decreased IgG and IgA levels. Some others, however, include decreased IgA level alone. We compared infants with decreased levels of IgG and IgA, all isotypes, and IgA alone.
To determine whether infants presenting with diminished IgA only differ clinically and in time of immunoglobulin recovery, from those with decreased levels of IgG and IgA, or of all major isotypes.
Eighty-seven term infants found to have immunoglobulin isotype(s) 2 or more SDs below mean, normal antibody response, intact cellular immunity, and absence of other immunodeficiency syndrome features were evaluated between January 1, 1977 and December 31, 2008. Infants had decreased IgA level (group 1, n = 43), decreased IgA and IgG levels (group 2, n = 39), or low IgA, IgG, and IgM levels (group 3, n = 5).
Groups had similar histories. Immunoglobulins normalized in a similar percentage of all groups during infancy but earlier for group 1 (P = .005).
Little reason exists to separate infants with isolated decreased IgA levels from those with decreased levels of IgA and IgG or all isotypes.
国际免疫学联合会将婴儿期暂时性低丙种球蛋白血症定义为 IgG 和 IgA 水平降低。然而，其他人也包括单独 IgA 水平降低。我们比较了 IgG 和 IgA 水平降低、所有同种型降低和单独 IgA 降低的婴儿。
确定仅表现为 IgA 减少的婴儿在临床和免疫球蛋白恢复时间上是否与 IgG 和 IgA 水平降低或所有主要同种型降低的婴儿不同。
1977 年 1 月 1 日至 2008 年 12 月 31 日，评估了 87 名足月婴儿，他们的免疫球蛋白同种型（s）水平比平均值低 2 或更多标准差，具有正常的抗体反应、完整的细胞免疫和无其他免疫缺陷综合征特征。婴儿有 IgA 水平降低（第 1 组，n = 43）、IgA 和 IgG 水平降低（第 2 组，n = 39）或低 IgA、IgG 和 IgM 水平（第 3 组，n = 5）。
各组具有相似的病史。在婴儿期，所有组的免疫球蛋白恢复正常的百分比相似，但第 1 组更早（P =.005）。
将单独 IgA 水平降低的婴儿与 IgA 和 IgG 水平降低或所有同种型降低的婴儿分开没有太多理由。
