Tezcan I, Ersoy F, Sanal O
Immunology Unit, Hacettepe University Institute of Child Health, Ankara.
Turk J Pediatr. 1992 Jan-Mar;34(1):1-4.
We evaluated IgG subclass levels in 11 symptomatic patients (ages between 3 and 22; mean 7.5 years) with IgA deficiency, seven with selective IgA deficiency, and four with low IgA levels. All patients had experienced three or more episodes of sinopulmonary infections a year. Combined IgG2-IgG4 deficiency was detected in two patients, IgG2 deficiency in one patient and IgG4 deficiency in two patients. Elevated IgG1 and IgG3 levels were detected in most of the IgG subclass deficient and sufficient patients. It is known that gammaglobulin replacement therapy reduces the frequency of infections significantly in IgG subclass deficiency. Although immunization against IgA is a risk in IgA deficiency, these patients can be treated with gammaglobulins containing low IgA.
我们评估了11例有症状的IgA缺乏患者（年龄在3至22岁之间；平均7.5岁）的IgG亚类水平，其中7例为选择性IgA缺乏，4例IgA水平较低。所有患者每年都经历过三次或更多次的鼻窦肺部感染。在两名患者中检测到IgG2-IgG4联合缺乏，一名患者存在IgG2缺乏，两名患者存在IgG4缺乏。在大多数IgG亚类缺乏和充足的患者中均检测到IgG1和IgG3水平升高。众所周知，丙种球蛋白替代疗法可显著降低IgG亚类缺乏患者的感染频率。虽然在IgA缺乏患者中接种IgA疫苗有风险，但这些患者可用含低IgA的丙种球蛋白进行治疗。
