Growth and Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India.
Nutrition. 2011 Jul-Aug;27(7-8):761-5. doi: 10.1016/j.nut.2010.07.017. Epub 2010 Oct 8.
Calcium intakes in underprivileged Indian children are often low. Improving calcium intake fortification of indigenous foods may be a viable strategy. The aim of this study was to evaluate calcium absorption, as judged by an acute increase in serum ionized calcium concentration, after ingestion of a calcium-fortified cereal-legume snack (laddoo).
Three groups of eight children (8-12 y old) with low habitual dietary calcium intake were recruited for the study. After an overnight fast, a calcium-fortified (500 mg of calcium carbonate) cereal-legume snack (laddoo) was given to group A, a similar but non-fortified snack was given to group B, and group C received calcium carbonate (500 mg) alone. Serum concentrations of ionized calcium and intact parathyroid hormone were measured at 0, 1, 2, 3, 4, and 5 h.
In group A, a peak of 6% above baseline was observed at 1 h in serum ionized calcium, whereas group C showed a peak of 5.5% at 4 h and group B showed a small increase of 1.8% at 1 h. The change in area under curve of groups A and C were of similar order (4.6 and 5.5, respectively), whereas that of group B was significantly lower (0.82). Serum parathyroid hormone was lowest at 2 h in groups A and B and at 3 h in group C.
The fortified cereal-legume laddoo may act as a novel vehicle for increasing calcium intake in children.
贫困印度儿童的钙摄入量往往较低。改善本土食物的钙强化摄入可能是一种可行的策略。本研究旨在评估摄入钙强化谷物-豆类零食（laddoo）后血清离子钙浓度的急性升高，以此来判断钙吸收情况。
本研究招募了三组低膳食钙摄入量的儿童（8-12 岁）。禁食过夜后，给 A 组食用钙强化（500mg 碳酸钙）的谷物-豆类零食（laddoo），B 组食用类似但未经强化的零食，C 组则单独服用碳酸钙（500mg）。在 0、1、2、3、4 和 5 小时测量血清离子钙和完整甲状旁腺激素的浓度。
A 组血清离子钙在 1 小时时较基线升高了 6%，而 C 组在 4 小时时升高了 5.5%，B 组在 1 小时时仅略有升高 1.8%。A 组和 C 组的曲线下面积变化相似（分别为 4.6 和 5.5），而 B 组的变化明显较低（0.82）。A 组和 B 组的甲状旁腺激素在 2 小时时最低，C 组则在 3 小时时最低。
强化谷物-豆类零食（laddoo）可能是增加儿童钙摄入量的一种新载体。
