Babraham Institute, Babraham, Cambridge, UK.
Autophagy. 2011 Jan;7(1):118-22. doi: 10.4161/auto.7.1.13697. Epub 2011 Jan 1.
We have recently proposed that some autophagosomes are formed within omegasomes, membrane sites connected to the endoplasmic reticulum and enriched in phosphatidylinositol 3-phosphate. In order to understand if there is any biological advantage to having such a precursor in autophagosome biogenesis, we generated a simple computer program that simulates omegasome and autophagosome formation under a variety of conditions. We concluded from running this simulation that having a transient precursor permits a bigger dynamic range of the autophagic response and allows a more efficient approach to steady state after autophagy stimulation.
我们最近提出，一些自噬体是在内体（omegasomes）中形成的，内体是与内质网相连的膜结构，富含磷脂酰肌醇 3-磷酸。为了了解在自噬体生物发生过程中存在这样的前体是否具有任何生物学优势，我们生成了一个简单的计算机程序，该程序可以在各种条件下模拟内体和自噬体的形成。通过运行该模拟，我们得出的结论是，存在短暂的前体可以使自噬反应的动态范围更大，并允许在自噬刺激后更快地达到稳态。
