全视野和焦点视网膜电图明视负反应在检测青光眼眼中的比较。
Comparison of photopic negative response of full-field and focal electroretinograms in detecting glaucomatous eyes.
作者信息
Machida Shigeki, Tamada Kunifusa, Oikawa Taku, Gotoh Yasutaka, Nishimura Tomoharu, Kaneko Muneyoshi, Kurosaka Daijiro
机构信息
Department of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, Japan.
出版信息
J Ophthalmol. 2011;2011. doi: 10.1155/2011/564131. Epub 2010 Sep 30.
Purpose. To compare the photopic negative response (PhNR) of the full-field electroretinogram (ERG) to the PhNR of the focal ERGs in detecting glaucoma. Methods. One hundred and three eyes with glaucoma and 42 normal eyes were studied. Full-field ERGs were elicited by red stimuli on a blue background. The focal ERGs were elicited by a 15° white stimulus spot centered on the macula, the superotemporal or the inferotemporal areas of the macula. Results. In early glaucoma, the areas under the receiver operating characteristic curves (AUCs) were significantly larger for the focal PhNR (0.863-0.924) than those for the full-field PhNR (0.666-0.748) (P < .05). The sensitivity was significantly higher for the focal PhNR than for the full-field PhNR in early (P < .01) and intermediate glaucoma (P < .05). In advanced glaucoma, there was no difference in the AUCs and sensitivities between the focal and full-field PhNRs. Conclusions. The focal ERG has the diagnostic ability with higher sensitivity in detecting early and intermediate glaucoma than the full-field ERG.
目的。比较全视野视网膜电图（ERG）的明视负反应（PhNR）与黄斑区局部ERG的PhNR在检测青光眼方面的差异。方法。对103只青光眼患眼和42只正常眼进行研究。全视野ERG由蓝色背景下的红色刺激诱发。局部ERG由以黄斑、黄斑颞上或颞下区域为中心的15°白色刺激光斑诱发。结果。在早期青光眼患者中，局部PhNR的受试者工作特征曲线下面积（AUC）（0.863 - 0.924）显著大于全视野PhNR的AUC（0.666 - 0.748）（P < 0.05）。在早期（P < 0.01）和中期青光眼（P < 0.05）患者中，局部PhNR的敏感性显著高于全视野PhNR。在晚期青光眼患者中，局部和全视野PhNR的AUC及敏感性无差异。结论。在检测早期和中期青光眼方面，局部ERG比全视野ERG具有更高的诊断能力和敏感性。
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