Department of Orthoptics, Faculty of Rehabilitation, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama, 701-0193, Japan.
Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.
Sci Rep. 2022 May 31;12(1):9091. doi: 10.1038/s41598-022-12971-2.
Electroretinography (ERG) is used to evaluate the physiological status of the retina and optic nerve. The purpose of this study was to determine the usefulness of ERGs recorded with the RETeval system in diagnosing optic nerve diseases. Forty-eight patients with optic nerve disorders, including optic neuritis, ischemic optic neuropathy, traumatic optic neuropathy, and dominant optic atrophy, and 36 normal control subjects were studied. The amplitudes of the photopic negative response (PhNR) were recorded with the RETeval system without mydriasis. The circumpapillary retinal nerve fiber layer thickness (cpRNFLT) was determined by optical coherence tomography (OCT). The significance of the correlations between the PhNR and cpRNFLT parameters were determined, and the receiver operating curve (ROC) analyses were performed for the PhNR and cpRNFLT. Patients with optic nerve disorders had significantly smaller PhNRs compared to the control subjects (P = 0.001). The ROC analyses indicated that both PhNR and cpRNFLT had comparable diagnostic abilities of detecting optic nerve disorders with PhNR at 0.857 and cpRNFLT at 0.764. The PhNR components recorded with the RETeval system have comparable diagnostic abilities as the cpRNFLT in diagnosing optic nerve disorders.
视网膜电图（ERG）用于评估视网膜和视神经的生理状态。本研究旨在确定使用 RETeval 系统记录的 ERG 在诊断视神经疾病中的有用性。研究了 48 例视神经疾病患者，包括视神经炎、缺血性视神经病变、外伤性视神经病变和显性视神经萎缩，以及 36 名正常对照者。使用 RETeval 系统在不散瞳的情况下记录明视负向反应（PhNR）的振幅。通过光学相干断层扫描（OCT）确定视网膜神经纤维层厚度（cpRNFLT）。确定 PhNR 与 cpRNFLT 参数之间相关性的显著性，并对 PhNR 和 cpRNFLT 进行受试者工作特征曲线（ROC）分析。与对照组相比，视神经疾病患者的 PhNR 明显较小（P=0.001）。ROC 分析表明，PhNR 和 cpRNFLT 均具有相当的诊断能力，PhNR 为 0.857，cpRNFLT 为 0.764。使用 RETeval 系统记录的 PhNR 成分在诊断视神经疾病方面与 cpRNFLT 具有相当的诊断能力。
