高效微波辅助一锅法制备含角型2,2-二甲基-2H-色酮的化合物
Efficient microwave-assisted one-pot preparation of angular 2,2-dimethyl-2H-chromone containing compounds.
作者信息
Zhou Ting, Shi Qian, Lee Kuo Hsing
机构信息
Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, USA.
出版信息
Tetrahedron Lett. 2010 Aug 18;51(33):4382-4386. doi: 10.1016/j.tetlet.2010.06.058.
Abstract
A novel and efficient microwave-assisted one-pot reaction was developed to synthesize angular 2,2-dimethyl-2H-chromone containing compounds, which is the first and key step in the synthesis of potent DCK and DCP anti-HIV agents. The newly developed microwave synthesis conditions dramatically shortened the reaction time from 2 days to 4 hours with improved yields.
摘要
开发了一种新颖且高效的微波辅助一锅法反应来合成含角型2,2-二甲基-2H-色酮的化合物，这是强效DCK和DCP抗HIV药物合成的第一步也是关键步骤。新开发的微波合成条件显著缩短了反应时间，从2天缩短至4小时，同时提高了产率。
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