GÜngÖr Tuğba
Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory,Çanakkale Onsekiz Mart University, Çanakkale Turkey.
Turk J Chem. 2021 Feb 17;45(1):219-230. doi: 10.3906/kim-2009-40. eCollection 2021.
A series of novel imidazo[1,2- ]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2- ]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by -toluenesulfonic acid under microwave-assisted conditions. The results showed that target compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields (46%-80%) under optimum reaction conditions. This method provides a green protocol for imidazo[1,2- ]pyrimidine containing tri/tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and one-pot multicomponent reaction as a green technique. The synthesized compounds have been elucidated using various spectroscopic tools such as FT-IR, H NMR, C NMR, and MS.
通过在微波辅助条件下，以咪唑并[1,2 - ]嘧啶 - 2 - 甲醛、联苯甲酰、伯胺和乙酸铵为原料，对甲苯磺酸催化，经连续两步一锅多组分反应，合成了一系列含三/四取代咪唑的新型咪唑并[1,2 - ]嘧啶衍生物（1 - 10）。结果表明，在最佳反应条件下，目标化合物可以从多种带有不同官能团的伯胺中获得，产率中等至良好（46% - 80%）。由于使用乙醇作为绿色溶剂、微波辐射作为更环保的加热方法以及一锅多组分反应作为绿色技术，该方法为含三/四取代咪唑的咪唑并[1,2 - ]嘧啶衍生物提供了一种绿色合成方案。已使用傅里叶变换红外光谱（FT - IR）、核磁共振氢谱（¹H NMR）、核磁共振碳谱（¹³C NMR）和质谱（MS）等各种光谱工具对合成的化合物进行了表征。
