药代动力学-药效学建模的概念与应用
Concepts and usefulness of pharmacokinetic-pharmacodynamic modelling.
作者信息
Holford N H
机构信息
Dept of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand.
出版信息
Fundam Clin Pharmacol. 1990;4 Suppl 2:93s-101s. doi: 10.1111/j.1472-8206.1990.tb00067.x.
Abstract
The combined application of pharmacokinetic and pharmacodynamic models to concentration and effect observations can be used to predict the consequences of alternative dosing strategies. Efficient experimental design is intimately related to the models that may be employed for data analysis. This is especially important in phase I studies which provide the basis for decisions on future clinical trials.
摘要
将药代动力学和药效学模型联合应用于浓度和效应观察，可用于预测不同给药策略的结果。高效的实验设计与可用于数据分析的模型密切相关。这在为未来临床试验决策提供依据的Ⅰ期研究中尤为重要。
Zotero 插件