Biological Sciences Division, Indian Statistical Institute, 203 B. T. Road, Calcutta, 700108, West Bengal, India.
Curr Microbiol. 2011 Mar;62(3):715-26. doi: 10.1007/s00284-010-9770-7. Epub 2010 Oct 10.
Despite discovery of the pathogen more than 100 years ago, tuberculosis (TB) continues to be a major killer disease worldwide. Currently a third of world population is infected and multiple-drug-resistant (mdr) TB registers maximum mortality by a single pathogen. Nanomedicine provides enormous opportunity for developing novel drugs. We have recently demonstrated surface-modified-lipophilic-nanosilica as drug to combat malaria and 100% lethal virus, BmNPV. Nanosilver possesses inherent antibacterial properties, but toxicity is a major concern. We hypothesized that capping with nature-inspired biomolecules, bovine serum albumin (BSA) and Poly-n-vinyl-pyrrolidone (PVP) used as blood volume extender, might insure biosafety. BSA-nano-Ag was found to be more stable than PVP-nano-Ag at physiological pH. In this first ever study on clinical isolates collected from TB endemic areas, we report, BSA-nano-Ag act as potent anti-TB drug. Further study with (human serum albumin)-nano-Ag and core-shell-nano-Ag could increase the biocompatibility of oral TB drug formulations without compromising on the efficacy of the drug.
尽管该病原体在 100 多年前就被发现了，但结核病（TB）仍然是全球主要的致死性疾病。目前，全球有三分之一的人口受到感染，而耐多药（MDR）结核病是单一病原体导致死亡率最高的疾病。纳米医学为开发新型药物提供了巨大的机会。我们最近已经证明，经过表面修饰的亲脂性纳米二氧化硅是一种对抗疟疾和 100%致死性病毒 BmNPV 的药物。纳米银具有固有的抗菌特性，但毒性是一个主要关注点。我们假设，用受自然启发的生物分子（牛血清白蛋白（BSA）和聚-n-乙烯基吡咯烷酮（PVP））作为血容量扩充剂进行封装，可能确保生物安全性。在生理 pH 值下，BSA-纳米银比 PVP-纳米银更稳定。在首次针对结核病流行地区采集的临床分离株进行的这项研究中，我们报告称，BSA-纳米银可作为有效的抗结核药物。进一步研究（人血清白蛋白）-纳米银和核壳纳米银可以提高口服结核病药物制剂的生物相容性，而不会影响药物的疗效。
