Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, ROC.
Org Lett. 2010 Nov 5;12(21):4812-5. doi: 10.1021/ol101969t.
A stereoselective synthesis of fully substituted cyclopentenes has been achieved by a sequential organocatalyzed Stetter and Michael-aldol condensation of aromatic aldehydes, nitroalkenes, and α,β-unsaturated aldehydes via the [1 + 2 + 2] annulation strategy with excellent diastereoselectivities and enantioselectivities (up to >99% ee).
通过[1+2+2]环加成策略，通过连续的有机催化 Stetter 和 Michael-aldol 缩合反应，实现了完全取代的环戊烯的立体选择性合成，该反应涉及芳香醛、硝基烯烃和α,β-不饱和醛，具有优异的非对映选择性和对映选择性（高达>99%ee）。
