Ford Pauline J, Raphael Sarah L, Cullinan Mary P, Jenkins Alicia J, West Malcolm J, Seymour Gregory J
The University of Queensland, School of Dentistry, 200 Turbot Street, Brisbane, QLD 4000, Australia.
Expert Rev Cardiovasc Ther. 2010 Oct;8(10):1483-93. doi: 10.1586/erc.10.109.
Oral health has been implicated in systemic disease throughout the ages; however, the understanding of the relationship between oral disease and systemic diseases such as cardiovascular disease and Type 2 diabetes mellitus is still emerging today. Chronic periodontal disease is widespread in the general population and a significant proportion of adults suffer from the most severe form of the disease. Dental plaque biofilm is necessary for the development of chronic periodontal disease with genetic and environmental factors contributing towards the pathogenesis. The putative biological mechanisms of the association between oral disease and atherogenesis are discussed, although there is insufficient evidence to establish causality at this time. Regardless of a direct causal relationship between oral disease and cardiovascular disease, treatment of oral disease leads to both a reduction in the systemic inflammatory burden as reflected in inflammatory markers and an improvement in endothelial function and hence improved overall health outcomes. A brief overview of periodontal disease including etiology, pathogenesis, screening and therapeutic implications is presented.
自古以来，口腔健康就与全身性疾病有关；然而，时至今日，人们对口腔疾病与心血管疾病和2型糖尿病等全身性疾病之间关系的认识仍在不断发展。慢性牙周病在普通人群中广泛存在，相当一部分成年人患有最严重形式的该疾病。牙菌斑生物膜是慢性牙周病发展所必需的，遗传和环境因素对其发病机制有影响。尽管目前尚无足够证据确定因果关系，但本文讨论了口腔疾病与动脉粥样硬化之间关联的假定生物学机制。无论口腔疾病与心血管疾病之间是否存在直接因果关系，治疗口腔疾病都会使炎症标志物所反映的全身性炎症负担减轻，内皮功能得到改善，从而改善整体健康状况。本文简要概述了牙周病，包括病因、发病机制、筛查及治疗意义。
