Khalife Dalia, Khalil Ali, Itani Mohamad N, Khalifeh Fatin, Faour Sara, Salame Anastasia, Ghazeeri Ghina
Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Lebanon.
Department of Dentistry, American University of Beirut Medical Center, Beirut, Lebanon.
Int J Womens Health. 2019 Jun 10;11:363-370. doi: 10.2147/IJWH.S202135. eCollection 2019.
Periodontal disease can lead to bacteremia with release of cytokines, affecting implantation in women trying to conceive through in vitro fertilization (IVF). A potential association between maternal periodontal disease and poor IVF outcomes has been described. The aim of the study is to assess whether pre-existing periodontal disease has any effect on IVF parameters. A pilot study composed of 34 women was conducted at a tertiary care center. Prior to IVF, dental examination, IVF parameters were collected. Thirty-four women participated in the study. The outcomes of 28 women (82.3%) were analyzed. Out of the 28 patients, 17 patients had a positive pregnancy test (60.7%) with a total of 13 live births (46.4%) and 4 pregnancy losses (14.3%). Plaque and bleeding index scores were both lower in patients who achieved pregnancy after IVF yet did not reach statistical significance (=0.309 and 0.422). Comparison of mean values for the different infertility parameters showed no significant differences among women with different IVF outcomes (>0.05). Different degrees of inflammation of the gingiva did not have an effect on the different clinical parameters and the live birth rates. The evidence provided by the present study does not support the hypothesis. Addressing the status of oral health before any infertility treatment remains to be elucidated.
牙周疾病可导致菌血症并释放细胞因子，影响通过体外受精（IVF）受孕的女性的着床。已有文献描述了孕产妇牙周疾病与体外受精不良结局之间的潜在关联。本研究的目的是评估既往存在的牙周疾病是否对体外受精参数有任何影响。在一家三级医疗中心开展了一项由34名女性组成的试点研究。在体外受精前，进行了牙科检查并收集了体外受精参数。34名女性参与了该研究。对28名女性（82.3%）的结局进行了分析。在这28名患者中，17名患者妊娠试验呈阳性（60.7%），共有13例活产（46.4%）和4例妊娠丢失（14.3%）。体外受精后成功妊娠但未达到统计学显著性的患者的菌斑指数和出血指数评分均较低（分别为=0.309和0.422）。不同不孕参数均值的比较显示，不同体外受精结局的女性之间无显著差异（>0.05）。不同程度的牙龈炎症对不同临床参数和活产率没有影响。本研究提供的证据不支持该假设。在任何不孕治疗前解决口腔健康状况仍有待阐明。
