磺吡酮和α-生育酚对血液透析患者血小板活化及功能的影响
The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients.
作者信息
Dmoszyńska-Giannopoulou A, Janicka L, Sokołowska B, Ksiazek A, Orłowska G, Janicki K
机构信息
Department of Haematology and Nephrology, Medical School, Lublin, Poland.
出版信息
Int Urol Nephrol. 1990;22(6):561-6. doi: 10.1007/BF02549745.
In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.
对30例接受慢性血液透析治疗的患者，在使用α-生育酚和磺吡酮进行抗血小板治疗之前及治疗期间，研究了血小板活性和功能。在两种治疗中，均观察到二磷酸腺苷（ADP）诱导的聚集和自发聚集显著降低。磺吡酮不仅对血小板聚集有抑制作用，而且对血小板因子3也有抑制作用，并导致出血时间显著延长。
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