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[Study on the transcript expression of p73 gene in human non-small cell lung cancer tissues.].

作者信息

He Y, Fan S, Jiang Y, Chen J, Li Z, Zhang H

机构信息

Department of Thoracic Surgery , Daping Hospital , The Third Military Medical University , Chongqing 400042 , P. R. China.

出版信息

Zhongguo Fei Ai Za Zhi. 2000 Feb 20;3(1):17-9. doi: 10.3779/j.issn.1009-3419.2000.01.06.

DOI:10.3779/j.issn.1009-3419.2000.01.06
PMID:20937205
Abstract

BACKGROUND

To explore the relationship among the p73 gene transcript expression and the oncogenesis , development of human non-small cell lung cancer (NSCLC) .

METHODS

The expression of p73 mRNA was detected in 32 human NSCLC tissues , para-cancer tissues , 7 lung benign lesion tissues and matched non-cancer lung tissues by semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) .

RESULTS

Overexpression of p73 mRNA was found in 28/ 32 NSCLC tissues. The positive expression rate of the p73 mRNA in the cancer tissues was significantly higher than that in the para-cancer tissues and benign lesion tissues either ( P < 0. 01) . No significant relationship was observed among p73 expression and differentiated grades , histoclassification and P-TNM stages of the cancer ( P > 0. 05) .

CONCLUSIONS

The results suggest that there is an overexpression of p73 mRNA in lung cancer tissues and it may paly an important role in the tumorigenesis and development in NSCLC.

摘要

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