为与老年人一起工作的医护人员接种流感疫苗：系统评价。
Influenza vaccination for healthcare workers who work with the elderly: systematic review.
机构信息
Department of Family Medicine, University of Calgary Medical Clinics North Hill, University of Calgary, 1707-1632 14 Avenue NW, Calgary, Canada T2M1M1.
出版信息
Vaccine. 2010 Dec 16;29(2):344-56. doi: 10.1016/j.vaccine.2010.09.085. Epub 2010 Nov 18.
AIM
To identify studies of influenza vaccination of HCWs and influenza in elderly residents in long-term care facilities.
SCOPE
We searched seven electronic databases for randomised controlled trials (RCTs) and non-RCTs. Two reviewers independently extracted data and assessed trial quality.
CONCLUSIONS
The key outcomes are serologically proven influenza, pneumonia, and deaths from pneumonia, and pooled data from three C-RCTs showed no effect. Pooled data from three C-RCTs showed lower resident all-cause mortality, but as influenza constituted less than 10% of all deaths even in epidemic years we question the appropriateness of this outcome measure. Pooled data from three C-RCTs showed vaccination of HCWs reduced ILI and data from one C-RCT that HCW vaccination reduced GP consultations for ILI, but as influenza constitutes less than 25% of ILI and we did not show that HCW influenza vaccination reduced serologically proven influenza we question whether this effect is due to confounding.
目的
确定医护人员接种流感疫苗和长期护理机构中老年人患流感的研究。
范围
我们在七个电子数据库中搜索了随机对照试验（RCT）和非 RCT。两位评审员独立提取数据并评估试验质量。
结论
主要结局是血清学证实的流感、肺炎和肺炎相关死亡，来自三项 C-RCT 的汇总数据显示无效果。来自三项 C-RCT 的汇总数据显示居民全因死亡率较低，但即使在流感流行年份，流感也不到所有死亡的 10%，因此我们对这一结局指标的适当性提出质疑。来自三项 C-RCT 的汇总数据显示医护人员接种疫苗可降低 ILI，一项 C-RCT 的数据显示医护人员接种疫苗可减少因 ILI 看全科医生的次数，但由于流感不到 ILI 的 25%，我们也没有证明医护人员接种流感疫苗可降低血清学证实的流感，因此我们质疑这种效果是否归因于混杂因素。
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