Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Antimicrob Agents Chemother. 2011 Jan;55(1):361-3. doi: 10.1128/AAC.01672-09. Epub 2010 Oct 11.
We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the bla(OXA-23) gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the bla(OXA-23) gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.
我们研究了由携带 bla(OXA-23) 基因的碳青霉烯类耐药鲍曼不动杆菌引起的疫情。在一组显示更高碳青霉烯类 MIC 的分离株中，发现一种新型插入序列（IS），命名为 ISAba10，插入 bla(OXA-23) 基因之前的 ISAba1 元件中。ISAba10 的存在与 OXA-23 表达的增加有关，可能是通过提供额外的启动子序列。在这些分离株中的大多数中，ISAba10 也插入到 carO 外膜蛋白基因中。
