Delmis J, Drazancić A, Jusić A, Petrić M
Medicinskog fakulteta u Zagrebu.
Lijec Vjesn. 1990 Sep-Oct;112(9-10):301-4.
Twenty-nine patients with myasthenia gravis in pregnancy have been presented. These patients represent a total of 31 deliveries and 33 newborns. Despite that myasthenia gravis is an illness that poses potentially grave complications for both mother and infant, there were no maternal and neonatal deaths. Only two patients experienced significant exacerbation of their disease during pregnancy. Most of patients underwent vaginal delivery. Cesarean section is not indicated unless there are obstetrical reasons. Incidence of cesarean section delivery was 16.1%. Vacuum extractor has been used to shorten the second stage of labor and its incidence was 16.1%. In the seven (22.6%) patients myasthenic signs and symptoms got worse during the postpartal period. Neonatal myasthenia gravis was observed in 13 (39.4%) newborns. Inverse relationship was found between neonatal myasthenia and duration of disease in mothers. Incidence of neonatal myasthenia was higher in newborns born by mothers with short duration of myasthenia gravis.
本文报告了29例妊娠合并重症肌无力患者。这些患者共分娩31次，新生儿33例。尽管重症肌无力是一种对母亲和婴儿都可能造成严重并发症的疾病，但未出现母婴死亡情况。只有2例患者在孕期病情显著加重。大多数患者经阴道分娩。除非有产科原因，否则不建议剖宫产。剖宫产率为16.1%。使用了真空吸引器来缩短第二产程，其发生率为16.1%。7例（22.6%）患者在产后肌无力体征和症状加重。13例（39.4%）新生儿出现新生儿重症肌无力。发现新生儿重症肌无力与母亲患病时长呈负相关。重症肌无力患病时长较短的母亲所生新生儿患新生儿重症肌无力的发生率更高。
