Escola Nacional de Saúde Publica Sérgio Arouca (ENSP), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
J Pediatr (Rio J). 2010 Sep-Oct;86(5):405-10. doi: 10.2223/JPED.2027.
To analyze trends in childhood leukemia mortality in the state of Rio de Janeiro, Brazil, between 1980 and 2006.
Gender-stratified leukemia mortality data for children aged < 15 years from 1980 to 2006 were retrieved from the Brazilian Mortality Information System for the state of Rio de Janeiro. Data were stratified by place of death (city of Rio de Janeiro proper, the state capital; Rio de Janeiro Metropolitan Region, excluding the capital; and rest of the state). Leukemia deaths were defined according to death certificate ICD-9 and ICD-10 coding (for deaths occurring in 1980-1995 and 1996-2006, respectively). Leukemia mortality rates were calculated by age and calendar year and age-adjusted to a standard world population. Polynomial linear regression with a 5% significance level was used to evaluate mortality trends in the study regions.
The three studied regions revealed similar trends, with a continuous downward pattern; the most substantial decline was detected in the municipality of Rio de Janeiro (city proper). In all studied areas, leukemia mortality was highest among males.
A downward trend in childhood leukemia mortality was detected throughout the state of Rio de Janeiro. The most pronounced reduction occurred in the state capital.
分析 1980 年至 2006 年巴西里约热内卢州儿童白血病死亡率的趋势。
从巴西里约热内卢州的国家死亡率信息系统中检索了 1980 年至 2006 年年龄<15 岁的儿童按性别分层的白血病死亡率数据。数据按死亡地点（里约热内卢市、州首府；里约热内卢大都市区，不包括首府；以及州的其他地区）分层。白血病死亡根据死亡证明 ICD-9 和 ICD-10 编码进行定义（分别用于 1980-1995 年和 1996-2006 年的死亡）。按年龄和日历年份计算白血病死亡率，并按标准世界人口进行年龄调整。使用具有 5%显着性水平的多项式线性回归评估研究区域的死亡率趋势。
三个研究区域均呈现出相似的趋势，呈持续下降模式；在里约热内卢市（市）中观察到的下降幅度最大。在所有研究区域中，白血病死亡率在男性中最高。
在整个里约热内卢州都检测到儿童白血病死亡率呈下降趋势。首府的降幅最大。
