Department of Radiology, New York University School of Medicine, New York, New York, USA.
Magn Reson Med. 2011 Jan;65(1):128-37. doi: 10.1002/mrm.22611.
Due to methodological difficulties related to the small size, variable distribution of hippocampal arteries, and the location of the hippocampus in the proximity of middle cranial fossa, little is known about hippocampal blood flow (HBF). We have tested the utility of a pulsed arterial spin labeling sequence based on multi-shot true fast imaging in steady precession to measure HBF in 34 normal volunteers (17 women, 17 men, 26-92 years old). Flow sensitivity to a mild hypercapnic challenge was also examined. Coregistered 3D MPRAGE sequence was used to eliminate from hippocampal and cortical regions of interest all voxel with <75% of gray matter. Large blood vessels were also excluded. HBF in normal volunteers averaged 61.2 ± 9.0 mL/(100 g min). There was no statistically significant age or gender effect. Under a mild hypercapnia challenge (end tidal CO(2) pressure increase of 6.8 ± 1.9 mmHg over the baseline), HBF response was 14.1 ± 10.8 mL/(100 g min), whereas cortical gray matter flow increased by 18.0 ± 12.2 mL/(100 g min). Flow response among women was significantly larger than in the men. The average absolute difference between two successive HBF measures was 3.6 mL/(100 g min) or 5.4%. The 3T true fast imaging in steady precession arterial spin labeling method offers a HBF measurement strategy that combines good spatial resolution, sensitivity, and minimal image distortions.
由于与海马体动脉体积小、分布不均以及海马体位置靠近中颅窝有关的方法学困难，人们对海马体血流（HBF）知之甚少。我们已经测试了一种基于多-shot 真实快速成像稳态进动的脉冲动脉自旋标记序列在 34 名正常志愿者（17 名女性，17 名男性，26-92 岁）中测量 HBF 的效用。还检查了对轻度高碳酸血症挑战的血流敏感性。使用配准的 3D MPRAGE 序列从海马体和皮质感兴趣区中消除所有灰度<75%的体素。还排除了大血管。正常志愿者的 HBF 平均为 61.2±9.0 mL/（100 g min）。年龄或性别均无统计学显著影响。在轻度高碳酸血症挑战下（基线时终末潮气 CO 2 压力增加 6.8±1.9 mmHg），HBF 反应为 14.1±10.8 mL/（100 g min），而皮质灰质血流增加 18.0±12.2 mL/（100 g min）。女性的血流反应明显大于男性。两次连续 HBF 测量的平均绝对差异为 3.6 mL/（100 g min）或 5.4%。3T 真实快速成像稳态进动动脉自旋标记法提供了一种 HBF 测量策略，结合了良好的空间分辨率、灵敏度和最小的图像失真。
