[Genetic thrombophilia and markers of endothelial activation in patients with preeclampsia].

BACKGROUND

The presence of thrombosis in preeclampsia suggests that endothelial function could play an important role in its pathogenesis.

OBJECTIVE

Determine the association between markers of genetic thrombophilia, endothelial activation and preeclampsia.

MATERIAL AND METHOD

Prospective study of cases and controls to determine the factor V Leiden existence, protrombin G20210A, methylenetetrahydrofolate reductase C677T, activated protein C resistance and levels of von Willebrand factor and the sFlt1 receptor were determined in 28 women with preeclampsia and 41 pregnant controls.

RESULTS

Methylenetetrahydrofolate reductase C677T had a high allelic frequency (0.50). Even in the absence of factor V Leiden, there were significant differences in the prevalence of activated protein C resistance and abnormal levels of sFlt1 between patients with preeclampsia homozygous for methylenetetrahydrofolate reductase C677T and controls (72 vs. 10%, p <0.008 and 63.6 vs. 10%, p < 0.05, respectively). Patients with two or more abnormal tests, including homozygousity for the C677T allele had an increased risk of preeclampsia than those with one or no abnormal test (OR: 3.15; CI: 1.1-9.02).

CONCLUSION

Methylenetetrahydrofolate reductase C677T has a high allelic prevalence and is associated with markers of thrombosis and endothelial activation in Mexican women with preeclampsia.