Fukunaga M, Tomomitsu T, Otsuka N, Imai H, Morita R, Nishii Y
Department of Nuclear Medicine, Kawasaki Medical School, Okayama, Japan.
Radiat Med. 1990 Nov-Dec;8(6):230-5.
A new photodensitometric technique (digital image processing, DIP) was performed to assess the bone mineral content of the metacarpal bone as a screening test for bone loss in 340 healthy or osteoporotic women as well as 35 steroid-dosed patients and 46 patients with chronic renal failure on hemodialysis. This procedure was compared with single photon absorptiometry and dual photon absorptiometry in terms of clinical value. Two bone mineral indexes, metacarpal index and sigma GS/D (the integrated bone mineral density of cortical and trabecular bone on a cross section in the middle of the second metacarpal bone), were equal to other methods in the quantification of decreases in bone mineral content due to aging in healthy or osteoporotic women. In addition, sigma GS/D was sensitive enough to detect decreases in bone mineral content in patients with vertebral fractures, on steroid therapy, and with chronic renal failure. Thus, sigma GS/D measured by DIP was shown to have clinical value as a tool in screening for decreased bone mineral content.
采用一种新的光密度测定技术（数字图像处理，DIP）来评估掌骨的骨矿物质含量，以此作为对340名健康或骨质疏松女性、35名使用类固醇药物的患者以及46名接受血液透析的慢性肾衰竭患者骨质流失的筛查测试。将该方法与单光子吸收法和双光子吸收法在临床价值方面进行了比较。在健康或骨质疏松女性中，两种骨矿物质指标，即掌骨指数和σGS/D（第二掌骨中部横截面皮质骨和小梁骨的综合骨矿物质密度）在量化因衰老导致的骨矿物质含量降低方面与其他方法相当。此外，σGS/D足够灵敏，能够检测出椎体骨折患者、接受类固醇治疗患者以及慢性肾衰竭患者的骨矿物质含量降低情况。因此，通过DIP测量的σGS/D作为筛查骨矿物质含量降低的工具具有临床价值。
