Andresen J, Nielsen H E
Clin Orthop Relat Res. 1982 Jun(166):104-11.
Metacarpal bone mass (D2-d2)/D2 measured on radiographs, and bone mineral content (BMC) measured by photon absorptiometry, were studied in the forearms of 30 nondialyzed and 25 hemodialyzed patients with chronic failure and in a group of normal subjects. Metacarpal bone mass was reduced in nondialyzed women with chronic renal failure and the amount of bone mineral reduced both in males and females with chronic renal failure, whereas these measurements were normal in dialyzed patients with chronic renal failure. Bone mineral content in the forearm and metacarpal bone mass decreased with age, both in women with chronic renal failure and in normal women, the decrease being more pronounced in women with chronic renal failure than in normal women. No age-related decrease was seen in males. Bone mineral content corrected for the size of bone (BMC') decreased with age both in males and in females. Highly significant correlations were found between metacarpal bone mass and BMC' in nondialyzed and dialyzed patients with chronic renal failure, whereas no significant correlation could be demonstrated in normal subjects. The study indicates that changes in metacarpal bone mass and in BMC to some degree occur simultaneously in patients with chronic renal failure; an accelerated loss of bone mass and of bone mineral with age may be seen in women with chronic renal failure compared to normal women.
对30例未接受透析的慢性肾衰竭患者、25例接受血液透析的慢性肾衰竭患者以及一组正常受试者的前臂进行研究，通过X光片测量掌骨骨量（D2 - d2）/D2，并采用光子吸收法测量骨矿物质含量（BMC）。未接受透析的慢性肾衰竭女性患者的掌骨骨量减少，慢性肾衰竭男性和女性患者的骨矿物质含量均降低，而接受透析的慢性肾衰竭患者的这些测量值正常。慢性肾衰竭女性患者和正常女性的前臂骨矿物质含量及掌骨骨量均随年龄增长而下降，慢性肾衰竭女性患者的下降更为明显。男性未见与年龄相关的下降。校正骨大小后的骨矿物质含量（BMC'）在男性和女性中均随年龄增长而下降。在未接受透析和接受透析的慢性肾衰竭患者中，掌骨骨量与BMC'之间存在高度显著的相关性，而在正常受试者中未发现显著相关性。该研究表明，慢性肾衰竭患者的掌骨骨量和BMC变化在一定程度上同时发生；与正常女性相比，慢性肾衰竭女性患者可能会出现随年龄增长骨量和骨矿物质加速流失的情况。
