Beijing Obstetrics Gynecology Hospital of Capital Medical University, Beijing, China.
Oncol Res. 2010;18(11-12):593-9. doi: 10.3727/096504010x12767359114045.
Recent studies have revealed that hScrib, the human homolog of Drosophila Scribble, is an apical-basal polarity determinant and an essential component of the adherens junction. In addition, hScrib has a critical role in the inhibition of cell proliferation through cell cycle progression. hScrib has been reported to be involved in the processes of many cancers, such as breast cancer, cervical cancer, colon carcinoma, etc.; however, the correlation between hScrib and endometrial cancer has not been identified. To address a possible role of hScrib in the development of endometrial cancer, we examined the localization and expression of hScrib in endometrial cancer. The present study demonstrated that decreased expression and changed localization of hScrib were associated with clinical stage, histopathological differentiation, and lymph node metastasis in endometrial cancer. hScrib might share an adherens junction with basolateral membrane partially by acting on E-cadherin in endometrial cancer. This evidence suggests that hScrib is involved in the development of endometrial cancer.
最近的研究表明，果蝇 Scribble 的人类同源物 hScrib 是顶端-基底极性决定因素和黏着连接的重要组成部分。此外，hScrib 通过细胞周期进展在抑制细胞增殖中起关键作用。已有报道称 hScrib 参与了多种癌症的发生，如乳腺癌、宫颈癌、结肠癌等；然而，hScrib 与子宫内膜癌之间的相关性尚未确定。为了研究 hScrib 在子宫内膜癌发展中的可能作用，我们检测了 hScrib 在子宫内膜癌中的定位和表达。本研究表明，hScrib 的表达降低和定位改变与子宫内膜癌的临床分期、组织病理学分化和淋巴结转移有关。hScrib 可能通过作用于子宫内膜癌中的 E-钙黏蛋白与基底外侧膜部分共享黏着连接。这一证据表明 hScrib 参与了子宫内膜癌的发生。
