α1-肾上腺素受体激动剂苯肾上腺素对 SART 应激诱导的大鼠直立性低血压的影响。
Effects of the α1-adrenoceptor agonist phenylephrine on SART stress-induced orthostatic hypotension in rats.
机构信息
Kinki University School of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, 577-8502, Japan.
出版信息
Biopsychosoc Med. 2010 Oct 12;4:13. doi: 10.1186/1751-0759-4-13.
BACKGROUND
Specific alternation of rhythm in temperature (SART)-stressed rats, an animal model of autonomic imbalance, exhibit low blood pressure and tachycardia during consciousness and under anesthesia. In addition, these rats easily develop orthostatic hypotension (OH) as a response to postural manipulation. Hence, we studied the influence of the adrenalin α1-receptor agonist phenylephrine on stress-induced OH in SART-stressed rats and unstressed rats.
METHODS
Male Wistar rats weighing 250-300 g were used. Rats were fixed in the supine position under urethane anesthesia. Blood pressure was directly measured from the left common carotid artery and ECG was recorded simultaneously.
RESULTS
The maximum decrease in blood pressure and the area under the blood pressure-time curve were both large, while the %reflex was small in the SART-stressed rats compared with unstressed rats. In the SART-stressed rats, prolonged intravenous administration of phenylephrine reduced OH at a dose that barely affected unstressed rats.
CONCLUSION
The results suggested that sympathetic dysfunction is a factor underlying SART stress-induced OH.
背景
特定节律交替的温度应激（SART）大鼠，自主神经失衡的动物模型，在清醒和麻醉状态下表现出低血压和心动过速。此外，这些大鼠很容易出现体位性低血压（OH）作为对姿势操作的反应。因此，我们研究了肾上腺素α1受体激动剂苯肾上腺素对 SART 应激大鼠和未应激大鼠应激诱导的 OH 的影响。
方法
雄性 Wistar 大鼠体重 250-300g。大鼠在乌拉坦麻醉下仰卧位固定。直接从左颈总动脉测量血压，同时记录心电图。
结果
与未应激大鼠相比，SART 应激大鼠的血压最大下降幅度和血压-时间曲线下面积均较大，而反射百分比较小。在 SART 应激大鼠中，苯肾上腺素静脉输注时间延长可降低 OH ，而对未应激大鼠的影响很小。
结论
结果表明，交感神经功能障碍是 SART 应激诱导 OH 的一个因素。
Zotero 插件