Hata T, Nishimura Y, Kita T, Kawabata A, Itoh E
Department of Pharmacology, Faculty of Pharmacy, Kinki University, Osaka, Japan.
Jpn J Pharmacol. 1987 Nov;45(3):365-72. doi: 10.1254/jjp.45.365.
The electrocorticogram (ECoG) in a SART (specific alternation of rhythm in temperature)-stressed (repeatedly cold-stressed) rat, which is regarded as an experimental model for clinical vagotonic-type dysautonomia, was investigated in the present study by the power spectral technique. 1) Analysis of ECoG in SART-stressed rats during the resting-arousal state indicated a decrease in total power and a decrease in relative power in the delta band, and also an increase in relative power in the theta, alpha and beta bands. 2) In the slow-wave sleeping state, the ECoG of SART-stressed rats indicated a marked increase in total power, an increase in the delta band and decreases in theta, alpha and beta bands. 3) Electric stimulation of the posterior-hypothalamic area evoked alterations of ECoG similar to those caused by SART stress. ECoG response to electric stimulation in SART-stressed rats was less than that in unstressed rats. 4) Lesioning of the posterior-hypothalamic areas prevented SART stress-induced ECoG alterations. SART-stressed rats thus appear to be at a higher consciousness level on awakening but to sleep more soundly. They seem to exhibit greater fluctuation in brain activity than normal rats. There is also the possibility that the posterior-hypothalamic area is responsible to some degree for ECoG alterations in SART-stressed rats.
在本研究中，通过功率谱技术对一种被视为临床迷走神经张力型自主神经功能障碍实验模型的、经SART（体温节律特异性交替）应激（反复冷应激）的大鼠的皮质电图（ECoG）进行了研究。1）对处于静息 - 觉醒状态的SART应激大鼠的ECoG分析表明，总功率降低，δ频段的相对功率降低，同时θ、α和β频段的相对功率增加。2）在慢波睡眠状态下，SART应激大鼠的ECoG显示总功率显著增加，δ频段功率增加，而θ、α和β频段功率降低。3）对下丘脑后部区域的电刺激诱发了与SART应激引起的类似的ECoG变化。SART应激大鼠对电刺激的ECoG反应小于未应激大鼠。4）下丘脑后部区域的损伤可防止SART应激诱导的ECoG变化。因此，SART应激大鼠似乎在觉醒时意识水平较高，但睡眠更安稳。它们似乎比正常大鼠表现出更大的脑活动波动。也有可能下丘脑后部区域在一定程度上对SART应激大鼠的ECoG变化负责。
