Hata T, Kita T, Namimatsu A, Itoh E, Oda Y
Nihon Yakurigaku Zasshi. 1982 Apr;79(4):335-42. doi: 10.1254/fpj.79.335.
In order to investigate the function of the circulatory system in SART rats, systolic blood pressure and regional arterial blood flow were examined. It was found in SART stressed rats that the blood pressure was about 10 mmHg lower than that of the non-stressed group on the 6th day of stressing and after stressing, and such low blood pressure was maintained for several days. SART rats showed a decrease in the average blood flow value in the common carotid artery, increases in the average and instantaneous maximum blood flow values in the superior mesenteric artery, and the instantaneous maximum blood flow value in the abdominal aorta had a tendency to increase, though little changes were observed in the renal and the femoral arteries. It was suggested by flow contours that there was hardening in the vessel walls of the common carotid artery and the abdominal aorta, and softening in the superior mesenteric artery. SART stress-induced hypotension was further decreased by a single dose of guanethidine, clonidine, or hydralazine, but not by neurotropin. Continuous preadministration of neurotropin prevented the SART stress-induced hypotension and changes in blood flow. From the above mentioned results, the sympathetic nerve may be thought to be decreased in tension, or be depressed, in the circulatory system of SART rats.
为了研究SART大鼠循环系统的功能，检测了收缩压和局部动脉血流量。结果发现，在应激第6天及应激后，SART应激大鼠的血压比非应激组低约10 mmHg，且这种低血压状态持续了数天。SART大鼠颈总动脉平均血流量值降低，肠系膜上动脉平均血流量值及瞬间最大血流量值增加，腹主动脉瞬间最大血流量值有增加趋势，而肾动脉和股动脉未见明显变化。血流轮廓图显示，颈总动脉和腹主动脉血管壁变硬，肠系膜上动脉血管壁变软。单剂量胍乙啶、可乐定或肼屈嗪可使SART应激诱导的低血压进一步降低，但神经妥乐平无此作用。连续预先给予神经妥乐平可预防SART应激诱导的低血压及血流变化。根据上述结果，可认为SART大鼠循环系统中交感神经张力降低或受到抑制。
