Department of Physiology, University of Arizona, Tucson, AZ, USA.
Physiology (Bethesda). 2010 Oct;25(5):304-10. doi: 10.1152/physiol.00016.2010.
Nebulin is a giant protein and a constituent of the skeletal muscle sarcomere. The name of this protein refers to its unknown (i.e., nebulous) function. However, recent rapid advances reveal that nebulin plays important roles in the regulation of muscle contraction. When these functions of nebulin are compromised, muscle weakness ensues, as is the case in patients with nemaline myopathy.
肌联蛋白是一种巨大的蛋白质，也是骨骼肌肌节的组成部分。这种蛋白质的名称指的是其未知的（即模糊的）功能。然而，最近的快速进展揭示了肌联蛋白在肌肉收缩的调节中起着重要作用。当肌联蛋白的这些功能受到损害时，就会出现肌肉无力，这就是杆状体肌病患者的情况。
