Masuda Kenta, Nishiwaki Hisashi, Akiyama Koichi, Yamauchi Satoshi, Maruyama Masafumi, Sugahara Takuya, Kishida Taro
Faculty of Agriculture, Ehime University, Matsuyama, Ehime, Japan.
Biosci Biotechnol Biochem. 2010;74(10):2071-6. doi: 10.1271/bbb.100422. Epub 2010 Oct 7.
The relationship between the structure of naturally occurring (7R,7'R,8R,8'R)-morinol B and its antifungal activity was examined. 3-Demethoxy morinol B showed much higher activity than the natural compound. The activity of the 4-butoxy-3-demethoxy derivative was higher than that of 3-demethoxy morinol B.
研究了天然存在的(7R,7'R,8R,8'R)-莫瑞诺醇B的结构与其抗真菌活性之间的关系。3-去甲氧基莫瑞诺醇B的活性比天然化合物高得多。4-丁氧基-3-去甲氧基衍生物的活性高于3-去甲氧基莫瑞诺醇B。
