Wilson T M, Ross P F, Rice L G, Osweiler G D, Nelson H A, Owens D L, Plattner R D, Reggiardo C, Noon T H, Pickrell J W
US Department of Agriculture, National Veterinary Services Laboratories, Ames 50010.
J Vet Diagn Invest. 1990 Jul;2(3):213-6. doi: 10.1177/104063879000200311.
During the fall of 1989, an episode of equine leukoencephalomalacia involved 18 of 66 purebred Arabian horses at a breeding/training stable in Arizona. Of the 18 horses affected, the condition was fatal in 14. These horses, as well as 48 unaffected horses, had been fed a diet containing a substantial amount of white corn screenings. Gross pathologic findings included liquefactive necrosis in parts of the cerebral white matter and hemorrhagic foci of various sizes in the brain stem. Histopathologic findings included rarefied white matter with pyknotic nuclei and eosinophilic cytoplasm. Thin-layer chromatography, high-performance liquid chromatography, and gas chromatography/mass spectroscopy were utilized to identify and quantitate fumonisin B1 in 3 samples of corn from the farm. Concentrations of fumonisin B1 range from 37 to 122 ppm. Fumonisin B2 was also detected. Using information on diet, animal weights, and feeding practices, estimates of total fumonisin B1 dosage were determined. This is the first definitive report on equine leukoencephalomalacia and associated fumonisin B1 concentrations.
1989年秋季，亚利桑那州一个繁殖/训练马场的66匹纯种阿拉伯马中有18匹患上了马脑软化症。在这18匹患病马匹中，有14匹死亡。这些患病马匹以及48匹未患病马匹都被喂食了一种含有大量白色玉米筛屑的饲料。大体病理检查结果包括大脑白质部分的液化性坏死以及脑干中大小不一的出血灶。组织病理学检查结果包括白质稀疏，细胞核固缩，细胞质嗜酸性变。利用薄层色谱法、高效液相色谱法和气相色谱/质谱分析法对该农场的3份玉米样本中的伏马毒素B1进行了鉴定和定量。伏马毒素B1的浓度范围为37至122 ppm。同时也检测到了伏马毒素B2。根据饮食、动物体重和喂食习惯等信息，确定了伏马毒素B1总剂量的估计值。这是关于马脑软化症及相关伏马毒素B1浓度的第一份确切报告。
