Vallarelli Andrelou Fralete Ayres, Harrison Simone Lee, Souza Elemir Macedo de
School of Medical Sciences, University of Campinas, Sao Paulo, SP, Brazil.
An Bras Dermatol. 2010 Jul-Aug;85(4):469-77. doi: 10.1590/s0365-05962010000400008.
Epidemiological studies have shown a significant relationship between melanocytic nevi and cutaneous melanoma.
To evaluate the development of melanocytic nevi in the pupils of a school composed primarily of children of Dutch descent and to assess the effect of environmental factors on these individuals whose phenotypic characteristics were similar to those of their ancestors.
In 1999 a cohort study was initiated to count the number of melanocytic nevi in 282 pupils of 3 to 17 years of age, 53.9% of whom were boys. Five years later a repeat exam was conducted in 148 students of 8 to 22 years of age, 49.3% of whom were males. The association between the age, skin phototype, eye color, hair color and ethnic group of the pupils and their parents and the presence of melanocytic nevi was analyzed at the beginning and at the end of the study.
There was a significant increase in cases of melanocytic nevi and dysplastic nevi at the follow-up examination. The number of melanocytic nevi was greater in boys than in girls in both covered and exposed areas of skin. Likelihood analysis calculated using the odds ratio showed that boys were more likely to develop melanocytic nevi than girls and that the children of non-mixed and mixed race with lighter hair were more likely to develop melanocytic nevi than those of other ethnic groups and those with dark hair. Children with skin phototype I were more likely to develop melanocytic nevi in covered areas of skin compared to those with skin types II or III.
These data show that individuals of Dutch descent were more likely to develop melanocytic nevi than individuals of other ethnic origins.
流行病学研究表明黑素细胞痣与皮肤黑色素瘤之间存在显著关联。
评估一所主要由荷兰裔儿童组成的学校学生中黑素细胞痣的发展情况，并评估环境因素对这些表型特征与其祖先相似的个体的影响。
1999年启动了一项队列研究，统计282名3至17岁学生的黑素细胞痣数量，其中53.9%为男孩。五年后，对148名8至22岁的学生进行了复查，其中49.3%为男性。在研究开始和结束时，分析了学生及其父母的年龄、皮肤光型、眼睛颜色、头发颜色和种族与黑素细胞痣存在情况之间的关联。
随访检查时，黑素细胞痣和发育异常痣的病例显著增加。在皮肤的遮盖部位和暴露部位，男孩的黑素细胞痣数量均多于女孩。使用优势比进行的似然分析表明，男孩比女孩更易发生黑素细胞痣，非混血和混血且头发较浅的儿童比其他种族和头发较深的儿童更易发生黑素细胞痣。与皮肤光型为II型或III型的儿童相比，皮肤光型为I型的儿童在皮肤遮盖部位更易发生黑素细胞痣。
这些数据表明，荷兰裔个体比其他种族个体更易发生黑素细胞痣。
