Pavlotsky F, Azizi E, Gurvich R, Lusky A, Barell V, Weiner M, Iscovich J
Department of Dermatology, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
Am J Epidemiol. 1997 Jul 1;146(1):78-86. doi: 10.1093/oxfordjournals.aje.a009193.
The role of host and environmental factors in the pathogenesis of multiple melanocytic nevi, atypical nevi, and freckles was studied in 1989 in a random sample of 3,040 Israeli males aged 17 years. Multiple melanocytic nevi were significantly associated with family history of melanoma or multiple melanocytic nevi (odds ratio (OR) = 15.0), fair or lightly pigmented skin color (OR = 2.7 and 2.3, respectively), and affiliation to the high or heterogenous melanoma risk group, determined by the incidence rates of melanoma in Jewish migrants from corresponding origin (OR = 3.1 and 2.1, respectively). An environment-related effect may account for the increased multiple melanocytic nevi risk among second- (OR = 8.2) compared with first-generation, native-born recruits (OR = 3.0) from the high melanoma risk group whose families had been living in Israel the longest. Atypical nevi were associated with fair (OR = 6.1) and lightly pigmented (OR = 3.5) skin color, high and moderate sunburn susceptibility (OR = 4.7 and 2.5, respectively), and family history of melanoma or multiple melanocytic nevi (OR = 4.7). Freckles were significantly associated with sun-sensitive phenotype, family history of melanoma or multiple melanocytic nevi (OR = 1.5). Conservative (OR = 1.9) or nonreligious status (OR = 1.9), and high (OR = 2.4) or heterogenous melanoma risk groups (OR = 1.8). These findings indicate that environmental factors may modify the occurrence of multiple melanocytic nevi and freckles in genetically susceptible ethnic groups.
1989年，在3040名17岁以色列男性的随机样本中，研究了宿主和环境因素在多发性黑素细胞痣、非典型痣和雀斑发病机制中的作用。多发性黑素细胞痣与黑色素瘤家族史或多发性黑素细胞痣显著相关（优势比（OR）=15.0），皮肤颜色白皙或色素沉着浅（OR分别为2.7和2.3），以及根据来自相应原籍的犹太移民中黑色素瘤发病率确定的高或异质性黑色素瘤风险组（OR分别为3.1和2.1）。与第一代在以色列生活时间最长的高黑色素瘤风险组的本地出生新兵（OR = 3.0）相比，第二代新兵（OR = 8.2）中多发性黑素细胞痣风险增加可能与环境相关效应有关。非典型痣与皮肤白皙（OR = 6.1）、色素沉着浅（OR = 3.5）、晒伤易感性高和中度（OR分别为4.7和2.5）以及黑色素瘤或多发性黑素细胞痣家族史（OR = 4.7）相关。雀斑与对阳光敏感的表型、黑色素瘤或多发性黑素细胞痣家族史显著相关（OR = 1.5）。保守（OR = 1.9）或无宗教信仰状态（OR = 1.9），以及高（OR = 2.4）或异质性黑色素瘤风险组（OR = 1.8）。这些发现表明，环境因素可能会改变遗传易感种族中多发性黑素细胞痣和雀斑的发生情况。
